ALTERATIONS IN SEMEN PARAMETERS IN MEN WITH EPILEPSY TREATED WITH VALPROATE; SHORT COMMUNICATION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KOSE OZLECE HATICE; ILIK FAIK; CECEN KURSAT; HUSEYINOGLU NERGIZ; SERIM ATAMAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Current Journal of Neurology Year:2015 | Volume:14 | Issue:3 Page(s): 164-167

Download Full-Text

View:

275

Download:

114

Cites:

Information Journal Paper

Title

ALTERATIONS IN SEMEN PARAMETERS IN MEN WITH EPILEPSY TREATED WITH VALPROATE; SHORT COMMUNICATION

Author(s)

Keywords

VALPROATE

MALE INFERTILITY

EPILEPSY

ANTIEPILEPTIC DRUGS

REPRODUCTIVE DYSFUNCTION

Abstract

Background: Besides the well-known adverse effects of VALPROATE (VPA), disorders related to male reproductive functions have been reported. Furthermore, only a limited number of previous studies have reported the relationship between VPA dose and impairment of the hormonal axis and semen quality. A patient with reversible changes that occurred in the sperm parameters after a dose increment of VPA. Methods: A 34-year-old male patient who was diagnosed with juvenile myoclonic EPILEPSY almost 15 years ago was admitted to our clinic. His seizures responded well to high doses of VPA treatment. Results: As the VPA dose was increased, consecutive semen analyses were performed and averaged for each dose; the results showed a remarkable decline in the sperm count and a manifest loss of sperm motility. VPA treatment was gradually diminished and stopped; meanwhile, treatment with another antiepileptic (lamotrigin) was initiated to control the patient’s seizures. Nine months later, the patient’s semen analysis was within normal ranges. After modification of the patient’s treatment regimen, he and his wife had a healthy baby.Conclusion: We suggest that VPA-dependent impairments in the hormone and semen analysis parameters were reversible after the termination of medical treatment, and that the VPA treatment did not cause permanent hormonal deregulation and, these side effects are dose dependent.

Cites

No record.

References

No record.

Cite

APA: Copy

KOSE OZLECE, HATICE, ILIK, FAIK, CECEN, KURSAT, HUSEYINOGLU, NERGIZ, & SERIM, ATAMAN. (2015). ALTERATIONS IN SEMEN PARAMETERS IN MEN WITH EPILEPSY TREATED WITH VALPROATE; SHORT COMMUNICATION. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(3), 164-167. SID. https://sid.ir/paper/665965/en

Vancouver: Copy

KOSE OZLECE HATICE, ILIK FAIK, CECEN KURSAT, HUSEYINOGLU NERGIZ, SERIM ATAMAN. ALTERATIONS IN SEMEN PARAMETERS IN MEN WITH EPILEPSY TREATED WITH VALPROATE; SHORT COMMUNICATION. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(3):164-167. Available from: https://sid.ir/paper/665965/en

IEEE: Copy

HATICE KOSE OZLECE, FAIK ILIK, KURSAT CECEN, NERGIZ HUSEYINOGLU, and ATAMAN SERIM, “ALTERATIONS IN SEMEN PARAMETERS IN MEN WITH EPILEPSY TREATED WITH VALPROATE; SHORT COMMUNICATION,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 3, pp. 164–167, 2015, [Online]. Available: https://sid.ir/paper/665965/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops