ASSESSMENT OF CLINICOPATHOLOGIC FEATURES IN PATIENTS WITH PITUITARY ADENOMAS IN NORTHEAST OF IRAN: A 13-YEAR RETROSPECTIVE STUDY

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ANVARI KAZEM; KALANTARI MAHMOUD REZA; SAMINI FARIBORZ; SHAHIDSALES SOODABEH; SEILANIAN TOUSSI MEHDI; GHORBANPOUR ZAKIYEH

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Journal: Current Journal of Neurology Year:2015 | Volume:14 | Issue:4 Page(s): 185-189

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Title

ASSESSMENT OF CLINICOPATHOLOGIC FEATURES IN PATIENTS WITH PITUITARY ADENOMAS IN NORTHEAST OF IRAN: A 13-YEAR RETROSPECTIVE STUDY

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Keywords

PITUITARY ADENOMA

FUNCTIONAL ADENOMA

SURVIVAL RATE

Abstract

Background: Intracranial lesions of the pituitary gland are common PITUITARY ADENOMAs, accounting for 6-10% of all symptomatic intracranial tumors. In this retrospective study, the clinicopathologic features and SURVIVAL RATE of PITUITARY ADENOMAs were evaluated.Methods: The present retrospective study was conducted on 83 patients with PITUITARY ADENOMAs, referring to radiation oncology departments of Ghaem and Omid Hospitals, Mashhad, Iran, over a period of 13 years (1999-2012). Data obtained from clinical records including clinical features, type of surgery (if performed), treatment modality, overall SURVIVAL RATE, and progression-free SURVIVAL RATE were analyzed. Results: Eighty-three patients including 44 males (53%) and 39 females (47%) participated in this study. The median age was 40 years (age range: 10-69 years). Chiasm compression was reported in 62 patients (74.4%), and 45.78% of the subjects suffered from headaches. Functional and nonfunctional adenomas were reported in 44 (53.01%) and 39 (46.99%) patients, respectively. In cases with functional and non-functional adenomas, the disease was controlled in 95 and 84.5% of the subjects for 3 years, respectively. Furthermore, 1- and 3-year SURVIVAL RATEs for FUNCTIONAL ADENOMA were 84.6 and 23%, respectively; the corresponding values were 90.9 and 22.7% in non-functional adenomas, respectively.Conclusion: In this study, a significant correlation between headache severity and type of adenoma was observed. So, application of surgery and radiotherapy together could be a highly effective approach for treating FUNCTIONAL ADENOMAs, although it is less efficient for the non-functional type.

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APA: Copy

ANVARI, KAZEM, KALANTARI, MAHMOUD REZA, SAMINI, FARIBORZ, SHAHIDSALES, SOODABEH, SEILANIAN TOUSSI, MEHDI, & GHORBANPOUR, ZAKIYEH. (2015). ASSESSMENT OF CLINICOPATHOLOGIC FEATURES IN PATIENTS WITH PITUITARY ADENOMAS IN NORTHEAST OF IRAN: A 13-YEAR RETROSPECTIVE STUDY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 14(4), 185-189. SID. https://sid.ir/paper/665968/en

Vancouver: Copy

ANVARI KAZEM, KALANTARI MAHMOUD REZA, SAMINI FARIBORZ, SHAHIDSALES SOODABEH, SEILANIAN TOUSSI MEHDI, GHORBANPOUR ZAKIYEH. ASSESSMENT OF CLINICOPATHOLOGIC FEATURES IN PATIENTS WITH PITUITARY ADENOMAS IN NORTHEAST OF IRAN: A 13-YEAR RETROSPECTIVE STUDY. CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2015;14(4):185-189. Available from: https://sid.ir/paper/665968/en

IEEE: Copy

KAZEM ANVARI, MAHMOUD REZA KALANTARI, FARIBORZ SAMINI, SOODABEH SHAHIDSALES, MEHDI SEILANIAN TOUSSI, and ZAKIYEH GHORBANPOUR, “ASSESSMENT OF CLINICOPATHOLOGIC FEATURES IN PATIENTS WITH PITUITARY ADENOMAS IN NORTHEAST OF IRAN: A 13-YEAR RETROSPECTIVE STUDY,” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 14, no. 4, pp. 185–189, 2015, [Online]. Available: https://sid.ir/paper/665968/en

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