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Information Journal Paper

Title

ASSOCIATION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE 86BP VNTR POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN SOUTH EAST OF IRAN

Pages

  51-54

Abstract

 Background: SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is an autoimmune disease with unknown etiology. INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL-1Ra) is naturally occurring cytokine that inhibits interleukin-1 (IL-1) activity by binding to the IL-1 receptors without signal transduction. The aim of this study was to investigate the association between IL- 1Ra gene 86bp VNTR POLYMORPHISM and SYSTEMIC LUPUS ERYTHEMATOSUS in the South- East of Iran.Materials and Methods: In this case control study, genetic POLYMORPHISM was analyzed in 163 SLE patients and 183 healthy controls. Genotyping of IL-1Ra VNTR POLYMORPHISM was determined by gel electrophoresis after PCR amplification.Results: IL-1Ra VNTR alleles have different copies of 86bp tandem repeats: allele 1 (four repeats), allele 2 (two repeats), allele 3 (five repeats), allele 4 (three repeats) and allele 5 (six repeats). We found an increased frequency of IL-1Ra allele 4 and 1/4 genotype in SLE patients compared to healthy controls (p=0.001 and p=0.002 respectively). Whereas, the frequency of IL-1Ra allele 3 was higher in controls than SLE patients (p=0.01). There was no any association between the IL-1Ra allele 2 and SLE. We did not observe any association between IL-1Ra POLYMORPHISM and SLE manifestations.Conclusion: We concluded that IL-1Ra allele 4 was involved in the pathogenesis of SLE. However, there was no association between the IL-1Ra allele 2 and SLE in South East of Iran.

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    APA: Copy

    MOHAMMADOO KHORASANI, MILAD, SALIMI, SAEEDEH, TABATABAI, EHSAN, SANDOUGHI, MAHNAZ, & ZAKERI, ZAHRA. (2014). ASSOCIATION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE 86BP VNTR POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN SOUTH EAST OF IRAN. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 16(12), 51-54. SID. https://sid.ir/paper/666148/en

    Vancouver: Copy

    MOHAMMADOO KHORASANI MILAD, SALIMI SAEEDEH, TABATABAI EHSAN, SANDOUGHI MAHNAZ, ZAKERI ZAHRA. ASSOCIATION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE 86BP VNTR POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN SOUTH EAST OF IRAN. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2014;16(12):51-54. Available from: https://sid.ir/paper/666148/en

    IEEE: Copy

    MILAD MOHAMMADOO KHORASANI, SAEEDEH SALIMI, EHSAN TABATABAI, MAHNAZ SANDOUGHI, and ZAHRA ZAKERI, “ASSOCIATION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE 86BP VNTR POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS IN SOUTH EAST OF IRAN,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 16, no. 12, pp. 51–54, 2014, [Online]. Available: https://sid.ir/paper/666148/en

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