INVESTIGATION OF FOXP3 GENETIC VARIATIONS AT POSITIONS -2383 C/T AND IVS9+459 T/C IN SOUTHERN IRANIAN PATIENTS WITH LUNG CARCINOMA

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FAZELZADEH HAGHIGHI MARYAM; GHAYUMI MOHAMMAD ALI; BEHZADNIA FARZANE; ERFANI NASROLLAH

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Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:5 Page(s): 465-471

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Title

INVESTIGATION OF FOXP3 GENETIC VARIATIONS AT POSITIONS -2383 C/T AND IVS9+459 T/C IN SOUTHERN IRANIAN PATIENTS WITH LUNG CARCINOMA

Author(s)

FAZELZADEH HAGHIGHI MARYAM | GHAYUMI MOHAMMAD ALI | BEHZADNIA FARZANE | ERFANI NASROLLAH | Issue Writer Certificate

Keywords

FOXP3GENE GENE

POLYMORPHISM

LUNG CANCER

PCR-RFLP

Abstract

Objective (s): FOXP3gene is an X-linked gene that encodes FOXP3 protein, an essential transcription factor in CD4+CD25+FOXP3+regulatory T (Treg) cells. We aimed, in the present study, to investigate the association of two FOXP3 POLYMORPHISMs, -2383 C/T (rs3761549) and IVS9+459 T/C (rs2280883), with LUNG CANCER.Materials and Methods: In a case-control study we analyzed genotypes and alleles frequencies at -2383 C/T and IVS9+459 T/C positions in 156 patients with LUNG CANCER and 156 age and sex matched healthy controls in Southern Iranian population, using polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP) methods. The data were verified by direct automated DNA sequencing.Results: The frequency of -2383 T allele was significantly higher in the patients than in the control group (11.8% versus 5.9%, P -value=0.04, OR=2.13, 95%CI=1.04-4.54). T allele frequency at IVS9+459 T/C position was higher, compared to the controls, in the patients who presented the disease over 55 years old (69.9% versus 59.1%, P -value=0.04, OR=1.61, 95%CI=1.01-2.55) and also in SCLC patients (77.8% versus 59.1%, P -value=0.03, OR=2.42, 95%CI=1.05-5.59). No significant differences were found in the genotypes and haplotypes distributions between the cases and controls. A high degree of linkage disequilibrium was observed between two POLYMORPHISMs.Conclusion: As the first study dealing with -2383 C/T and IVS9+459 T/C in LUNG CANCER, our data conclusively suggest the association of -2383 T allele with susceptibility to LUNG CANCER in Iranian population. The association of IVS9+459 T allele with susceptibility to LUNG CANCER in old patients suggests the age-dependent effects of FOXP3 gene on cancer occurrence.

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APA: Copy

FAZELZADEH HAGHIGHI, MARYAM, GHAYUMI, MOHAMMAD ALI, BEHZADNIA, FARZANE, & ERFANI, NASROLLAH. (2015). INVESTIGATION OF FOXP3 GENETIC VARIATIONS AT POSITIONS -2383 C/T AND IVS9+459 T/C IN SOUTHERN IRANIAN PATIENTS WITH LUNG CARCINOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(5), 465-471. SID. https://sid.ir/paper/666947/en

Vancouver: Copy

FAZELZADEH HAGHIGHI MARYAM, GHAYUMI MOHAMMAD ALI, BEHZADNIA FARZANE, ERFANI NASROLLAH. INVESTIGATION OF FOXP3 GENETIC VARIATIONS AT POSITIONS -2383 C/T AND IVS9+459 T/C IN SOUTHERN IRANIAN PATIENTS WITH LUNG CARCINOMA. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(5):465-471. Available from: https://sid.ir/paper/666947/en

IEEE: Copy

MARYAM FAZELZADEH HAGHIGHI, MOHAMMAD ALI GHAYUMI, FARZANE BEHZADNIA, and NASROLLAH ERFANI, “INVESTIGATION OF FOXP3 GENETIC VARIATIONS AT POSITIONS -2383 C/T AND IVS9+459 T/C IN SOUTHERN IRANIAN PATIENTS WITH LUNG CARCINOMA,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 5, pp. 465–471, 2015, [Online]. Available: https://sid.ir/paper/666947/en

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