EFFICACY OF DULOXETINE ADD ON IN TREATMENT OF INFLAMMATORY BOWEL DISEASE PATIENTS: A DOUBLE-BLIND CONTROLLED STUDY

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DAGHAGHZADEH HAMED; NAJI FATEME; AFSHAR HAMID; SHARBAFCHI MOHAMMAD REZA; FEIZI AWAT; MAROUFI MOHSEN; TABATABAEIAN MAHSHID; ADIBI PEYMAN; TAVAKOLI HAMID

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2015 | Volume:20 | Issue:6 Page(s): 595-601

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Title

EFFICACY OF DULOXETINE ADD ON IN TREATMENT OF INFLAMMATORY BOWEL DISEASE PATIENTS: A DOUBLE-BLIND CONTROLLED STUDY

Author(s)

Keywords

ANXIETY

DEPRESSION

DULOXETINE

INFLAMMATORY BOWEL DISEASE

QUALITY OF LIFE

SYMPTOM SEVERITY

Abstract

Background: Treating INFLAMMATORY BOWEL DISEASE (IBD) with antidepressants might be of utility to improve patient’s condition. The aim of this study was to assess the efficacy of DULOXETINE on DEPRESSION, ANXIETY, severity of symptoms, and QUALITY OF LIFE (QOL) in IBD patients. Materials and Methods: In a randomized, double-blind, controlled clinical trial on 2013-2014, in Alzahra Hospital (Isfahan, Iran), 44 IBD patients were chosen to receive either DULOXETINE (60 mg/day) or placebo. They were treated in a 12 weeks program, and all of the participants also received mesalazine, 2-4 g daily. We assessed ANXIETY and DEPRESSION with Hospital ANXIETY and DEPRESSION Scale, the severity of symptoms with Lichtiger Colitis Activity Index and QOL with World Health Organization QUALITY OF LIFE Instruments, before and just after the treatment. The data were analyzed using Paired sample t -test and ANCOVA.Results: In 35 subjects who completed the study, the mean (standard error [SE]) scores of DEPRESSION and ANXIETY were reduced in DULOXETINE more than placebo group, significantly (P=0.041 and P=0.049, respectively). The mean (SE) scores of severity of symptom were also reduced in DULOXETINE more than the placebo group, significantly (P=0.02). The mean (SE) scores of physical, psychological, and social dimensions of QOL were increased after treatment with DULOXETINE more than placebo group, significantly (P=0.001, P=0.038, and P=0.015, respectively). The environmental QOL was not increased significantly (P=0.260).Conclusion: DULOXETINE is probably effective and safe for reducing DEPRESSION, ANXIETY and severity of physical symptoms. It also could increase physical, psychological, and social QOL in patients.

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APA: Copy

DAGHAGHZADEH, HAMED, NAJI, FATEME, AFSHAR, HAMID, SHARBAFCHI, MOHAMMAD REZA, FEIZI, AWAT, MAROUFI, MOHSEN, TABATABAEIAN, MAHSHID, ADIBI, PEYMAN, & TAVAKOLI, HAMID. (2015). EFFICACY OF DULOXETINE ADD ON IN TREATMENT OF INFLAMMATORY BOWEL DISEASE PATIENTS: A DOUBLE-BLIND CONTROLLED STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(6), 595-601. SID. https://sid.ir/paper/667010/en

Vancouver: Copy

DAGHAGHZADEH HAMED, NAJI FATEME, AFSHAR HAMID, SHARBAFCHI MOHAMMAD REZA, FEIZI AWAT, MAROUFI MOHSEN, TABATABAEIAN MAHSHID, ADIBI PEYMAN, TAVAKOLI HAMID. EFFICACY OF DULOXETINE ADD ON IN TREATMENT OF INFLAMMATORY BOWEL DISEASE PATIENTS: A DOUBLE-BLIND CONTROLLED STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(6):595-601. Available from: https://sid.ir/paper/667010/en

IEEE: Copy

HAMED DAGHAGHZADEH, FATEME NAJI, HAMID AFSHAR, MOHAMMAD REZA SHARBAFCHI, AWAT FEIZI, MOHSEN MAROUFI, MAHSHID TABATABAEIAN, PEYMAN ADIBI, and HAMID TAVAKOLI, “EFFICACY OF DULOXETINE ADD ON IN TREATMENT OF INFLAMMATORY BOWEL DISEASE PATIENTS: A DOUBLE-BLIND CONTROLLED STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 6, pp. 595–601, 2015, [Online]. Available: https://sid.ir/paper/667010/en

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