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Information Journal Paper

Title

CALCITRIOL MODULATES THE EFFECTS OF BONE MARROW‐DERIVED MESENCHYMAL STEM CELLS ON MACROPHAGE FUNCTIONS

Author(s)

 MANSOURI MOTLAGH BAHMAN | AFZALE AHANGARAN NAHIDEH | ABTAHI FROUSHANI SEYYED MEYSAM | Issue Writer Certificate 

Pages

  672-676

Abstract

 Objective (s): Some evidence showed that CALCITRIOL has an important role in regulating growth and differentiation of MESENCHYMAL STEM CELLs (MSCs). However, the interaction between MESENCHYMAL STEM CELLs and MACROPHAGE is not clear yet. The current study was done to investigate thein vitro effects of CALCITRIOL on the interactions between bone marrow‐derived MSCs and rat MACROPHAGEs.Materials and Methods: MSCs were isolated from rat bone marrow and pulsed with different concentrations of CALCITRIOL (50, 100 and 200 nanomolar) for 24, 48 and 72 hr. Then, MESENCHYMAL STEM CELLs were co‐cultured with MACROPHAGEs for 4 hr. Finally, MACROPHAGEs were evaluated for ability to uptake neutral red, phagocytosis activity against opsonized yeast, respiratory burst and viability.Results: Our data showed that bone marrow‐derived MSCs pulsed with CALCITRIOL may cause a significant increase in uptake of neutral red and phagocytic activity of opsonized heat killed baker' s yeast. Moreover, treatment of MSCs with CALCITRIOL enhanced MACROPHAGE viability. Nevertheless, the respiratory burst of MACROPHAGEs was significantly reduced in MACROPHAGEs co‐cultured with CALCITRIOL‐treated MSCs compared to control group.Conclusion: CALCITRIOL may accelerate and potentiate anti‐inflammatory M2 MACROPHAGE polarization by MSCs.

Cites

References

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    • Cite

    APA: Copy

    MANSOURI MOTLAGH, BAHMAN, AFZALE AHANGARAN, NAHIDEH, & ABTAHI FROUSHANI, SEYYED MEYSAM. (2015). CALCITRIOL MODULATES THE EFFECTS OF BONE MARROW?DERIVED MESENCHYMAL STEM CELLS ON MACROPHAGE FUNCTIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(7), 672-676. SID. https://sid.ir/paper/667031/en

    Vancouver: Copy

    MANSOURI MOTLAGH BAHMAN, AFZALE AHANGARAN NAHIDEH, ABTAHI FROUSHANI SEYYED MEYSAM. CALCITRIOL MODULATES THE EFFECTS OF BONE MARROW?DERIVED MESENCHYMAL STEM CELLS ON MACROPHAGE FUNCTIONS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(7):672-676. Available from: https://sid.ir/paper/667031/en

    IEEE: Copy

    BAHMAN MANSOURI MOTLAGH, NAHIDEH AFZALE AHANGARAN, and SEYYED MEYSAM ABTAHI FROUSHANI, “CALCITRIOL MODULATES THE EFFECTS OF BONE MARROW?DERIVED MESENCHYMAL STEM CELLS ON MACROPHAGE FUNCTIONS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 7, pp. 672–676, 2015, [Online]. Available: https://sid.ir/paper/667031/en

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