مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

295
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

200
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CORRELATIONAL STUDIES ON INSULIN RESISTANCE AND LEPTIN GENE POLYMORPHISMS IN PERITONEAL DIALYSIS PATIENTS

Pages

  878-886

Abstract

 Objective (s): The aim of the study was to investigate the relationship between INSULIN RESISTANCE (IR) and LEPTIN (LEP) gene POLYMORPHISMS in PERITONEAL DIALYSIS (PD) patients.Materials and Methods: From July 1, 2011 to August 1, 2011, patients who received chronic PD were chosen and divided into three groups (DM, high HOMR‐IR, and low HOMR‐IR). Two PCR products of LEP were sequenced and aligned and the distribution of POLYMORPHISMS was analyzed using χ2 analysis. In addition, serum LEPTIN level, PD conditions, and biochemical parameters according to different genotype of G‐2548A and A19G were statistically analyzed (P‐value<0.05). The relationship between LEP gene POLYMORPHISMS and prognosis was explored.Results: Totally 157 patients with average age of 55±15 years old were chosen. Distribution of genotype frequencies was complied with Hardy‐Weinberg equilibrium. LEPTIN level and BMI (body mass index) of the GG genotype of G‐2548A were higher than that of GA or AA. The fasting glucose, cholesterol, etc. of AA genotype were lower, and the nPCR was higher than the two other genotypes. Serum LEPTIN level and BMI of AA genotype of A19G was higher than GA and GG genotypes; meanwhile, fasting blood glucose of that genotypes was the highest. In addition, survival rate of AA group of A19G was very low.Conclusion: The G‐2548A and A19G POLYMORPHISMS were correlated with serum LEPTIN level and IR. LEPTIN A19G polymorphism may be prognostic for PD patients. This study may facilitate early intervention for IR in PD patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    CAO, LIOU, MOU, SHAN, WEI, FANG, QI, CHAOJUN, CHANG, XINBEI, GU, LEYI, QIAN, JIAQI, & NI, ZHAOHUI. (2015). CORRELATIONAL STUDIES ON INSULIN RESISTANCE AND LEPTIN GENE POLYMORPHISMS IN PERITONEAL DIALYSIS PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 878-886. SID. https://sid.ir/paper/667063/en

    Vancouver: Copy

    CAO LIOU, MOU SHAN, WEI FANG, QI CHAOJUN, CHANG XINBEI, GU LEYI, QIAN JIAQI, NI ZHAOHUI. CORRELATIONAL STUDIES ON INSULIN RESISTANCE AND LEPTIN GENE POLYMORPHISMS IN PERITONEAL DIALYSIS PATIENTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):878-886. Available from: https://sid.ir/paper/667063/en

    IEEE: Copy

    LIOU CAO, SHAN MOU, FANG WEI, CHAOJUN QI, XINBEI CHANG, LEYI GU, JIAQI QIAN, and ZHAOHUI NI, “CORRELATIONAL STUDIES ON INSULIN RESISTANCE AND LEPTIN GENE POLYMORPHISMS IN PERITONEAL DIALYSIS PATIENTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 878–886, 2015, [Online]. Available: https://sid.ir/paper/667063/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button