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Information Journal Paper

Title

BIOCHEMICAL CHANGES IN BLOOD OF TYPE 2 DIABETES WITH AND WITHOUT METABOLIC SYNDROME AND THEIR ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS

Pages

  763-770

Keywords

NA+/K+-ATPASE ACTIVITY 

Abstract

 Background: Multiple factors are involved in the development and progression of TYPE 2 DIABETES mellitus (DMII) to DMII with METABOLIC SYNDROME (MetS) and cardiovascular complications. To identify some of these factors, we aim to investigate the changes in erythrocyte membrane Na+/K+-ATPase activity, serum glucose, insulin, LIPID PROFILE, hemoglobin A1C (HbA1c), high-sensitivity C-reactive protein (hs-CRP), anthropometric measurements, and blood pressure in DMII with and without MetS.Materials and Methods: This cross-sectional study comprised 155 male subjects distributed into three groups as healthy controls (50 non-DMII volunteers), Group I (50 DMII without MetS), and Group II (55 DMII with MetS). Fasting blood samples were taken for the measurement of glucose, insulin, HbA1c, hs-CRP and LIPID PROFILE. Na+/K+-ATPase activity was determined in erythrocyte ghost.Results: Na+/K+-ATPase activity was significantly decreased in DMII groups compared with controls. No significant difference was shown in Na+/K+-ATPase activity between DMII groups. Total ATPase activity, total cholesterol and low-density lipoproteincholesterol levels were similar in the three groups. Levels of insulin, hs-CRP, triacylglycerols, systolic blood pressure, weight, waist and hip circumference, waist/hip ratio, and body mass index were significantly elevated and high-density lipoprotein-cholesterol significantly decreased only in Group II. Significant differences in serum glucose and hip circumference were seen between the groups.No significant differences in HbA1c levels were observed between DMII groups.Conclusion: Changes in many of the measured risk factors that occurred only in Group II compared with controls and Group I may provide an explanation of how DMII progresses to DMII with MetS and future cardiovascular complications.

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    APA: Copy

    ZADHOUSH, FOUZIEH, SADEGHI, MASOUMEH, & POURFARZAM, MORTEZA. (2015). BIOCHEMICAL CHANGES IN BLOOD OF TYPE 2 DIABETES WITH AND WITHOUT METABOLIC SYNDROME AND THEIR ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(8), 763-770. SID. https://sid.ir/paper/667681/en

    Vancouver: Copy

    ZADHOUSH FOUZIEH, SADEGHI MASOUMEH, POURFARZAM MORTEZA. BIOCHEMICAL CHANGES IN BLOOD OF TYPE 2 DIABETES WITH AND WITHOUT METABOLIC SYNDROME AND THEIR ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(8):763-770. Available from: https://sid.ir/paper/667681/en

    IEEE: Copy

    FOUZIEH ZADHOUSH, MASOUMEH SADEGHI, and MORTEZA POURFARZAM, “BIOCHEMICAL CHANGES IN BLOOD OF TYPE 2 DIABETES WITH AND WITHOUT METABOLIC SYNDROME AND THEIR ASSOCIATION WITH METABOLIC SYNDROME COMPONENTS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 8, pp. 763–770, 2015, [Online]. Available: https://sid.ir/paper/667681/en

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