PRESENTATION OF A NOVEL MODEL OF CHITOSAN‐ POLYETHYLENE OXIDE‐NANOHYDROXYAPATITE NANOFIBERS TOGETHER WITH BONE MARROW STROMAL CELLS TO REPAIR AND IMPROVE MINOR BONE DEFECTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EMAMGHOLI ASGAR; RAHIMI MOHSEN; KAKA GHOLAM REZA; SADRAIE SEYED HOMAYOON; NAJAFI SALEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:9 Page(s): 887-893

Download Full-Text

View:

294

Download:

208

Cites:

Information Journal Paper

Title

PRESENTATION OF A NOVEL MODEL OF CHITOSAN‐ POLYETHYLENE OXIDE‐NANOHYDROXYAPATITE NANOFIBERS TOGETHER WITH BONE MARROW STROMAL CELLS TO REPAIR AND IMPROVE MINOR BONE DEFECTS

Author(s)

Keywords

BMSCS

CHITOSAN

NANOFIBERS

SCAFFOLDS

Abstract

Objective (s): Various methods for repairing bone defects are presented. Cell therapy is one of these methods. Bone marrow stromal cells (BMSCS) seem to be suitable for this purpose. On the other hand, lots of biomaterials are used to improve and repair the defect in the body, so in this study we tried to produce a similar structure to the bone by the CHITOSAN and hydroxyapatite.Materials and Methods: In this study, the solution of CHITOSAN‐nanohydroxyapatite‐polyethylene oxide (PEO) NANOFIBERS was produced by electrospinning method, and then the BMSCS were cultured on this solution. A piece of CHITOSAN‐nanohydroxyapatite NANOFIBERS with BMSCS was placed in a hole with the diameter of 1 mm at the distal epiphysis of the rat femur. Then the biomechanical and radiographic studies were performed.Results: Biomechanical testing results showed that bone strength was significantly higher in the Nanofiber/BMSCS group in comparison with control group. Also the bone strength in nanofiber/BMSCS group was significant, but in nanofiber group was nearly significant. Radiographic studies also showed that the average amount of callus formation (radio opacity) in nanofiber and control group was not significantly different. The callus formation in nanofiber/BMSCS group was increased compared to the control group, and it was not significant in the nanofiber group.Conclusion: Since CHITOSAN‐nanohydroxyapatite NANOFIBERS with BMSCS increases the rate of bone repair, the obtained cell‐nanoscaffold shell can be used in tissue engineering and cell therapy, especially for bone defects.

Cites

No record.

References

No record.

Cite

APA: Copy

EMAMGHOLI, ASGAR, RAHIMI, MOHSEN, KAKA, GHOLAM REZA, SADRAIE, SEYED HOMAYOON, & NAJAFI, SALEH. (2015). PRESENTATION OF A NOVEL MODEL OF CHITOSAN? POLYETHYLENE OXIDE?NANOHYDROXYAPATITE NANOFIBERS TOGETHER WITH BONE MARROW STROMAL CELLS TO REPAIR AND IMPROVE MINOR BONE DEFECTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 887-893. SID. https://sid.ir/paper/667840/en

Vancouver: Copy

EMAMGHOLI ASGAR, RAHIMI MOHSEN, KAKA GHOLAM REZA, SADRAIE SEYED HOMAYOON, NAJAFI SALEH. PRESENTATION OF A NOVEL MODEL OF CHITOSAN? POLYETHYLENE OXIDE?NANOHYDROXYAPATITE NANOFIBERS TOGETHER WITH BONE MARROW STROMAL CELLS TO REPAIR AND IMPROVE MINOR BONE DEFECTS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):887-893. Available from: https://sid.ir/paper/667840/en

IEEE: Copy

ASGAR EMAMGHOLI, MOHSEN RAHIMI, GHOLAM REZA KAKA, SEYED HOMAYOON SADRAIE, and SALEH NAJAFI, “PRESENTATION OF A NOVEL MODEL OF CHITOSAN? POLYETHYLENE OXIDE?NANOHYDROXYAPATITE NANOFIBERS TOGETHER WITH BONE MARROW STROMAL CELLS TO REPAIR AND IMPROVE MINOR BONE DEFECTS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 887–893, 2015, [Online]. Available: https://sid.ir/paper/667840/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops