مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

RESVERATROL AND LIVER: A SYSTEMATIC REVIEW

Pages

  797-810

Abstract

 Background: Recent studies demonstrated that RESVERATROL has many therapeutic effects on LIVER disorders. RESVERATROL significantly increased survival after LIVER transplantation, decreased fat deposition, necrosis, and apoptosis which induced by ischemia in Wistar rats. It provided LIVER protection against chemical, cholestatic, and alcohol injury. RESVERATROL can improve glucose metabolism and lipid profile and decrease LIVER FIBROSIS and STEATOSIS. Furthermore, it was able to alter hepatic cell fatty acid composition. According to extension of LIVER disease around the world and necessity of finding new threat, this review critically examines the current preclinical in vitroand in vivo studies on the preventive and therapeutic effects of RESVERATROL in LIVER disorders.Materials and Methods: A search in PubMed, Google Scholar, and Scopus was undertaken to identify relevant literature using search terms, including “liver, ” “hepatic, ” and “Resveratrol.” Bothin vivo and in vitro studies were included. No time limiting considered for this search.Results: A total of 76 articles were eligible for this review. In these articles, RESVERATROL shows antioxidative properties in different models of hepatitis resulting in reducing of hepatic FIBROSIS.Conclusion: RESVERATROL could reduce hepatic STEATOSIS through modulating the insulin resistance and lipid profile in animals. These high quality preclinical studies propose the potential therapeutic implication of RESVERATROL in LIVER disorders especially those with hepatic STEATOSIS. RESVERATROL can play a pivotal role in prevention and treatment of LIVER disorders by reducing hepatic FIBROSIS.

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    Cite

    APA: Copy

    FAGHIHZADEH, FOROUZAN, HEKMATDOOST, AZITA, & ADIBI, PAYMAN. (2015). RESVERATROL AND LIVER: A SYSTEMATIC REVIEW. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 20(8), 797-810. SID. https://sid.ir/paper/668069/en

    Vancouver: Copy

    FAGHIHZADEH FOROUZAN, HEKMATDOOST AZITA, ADIBI PAYMAN. RESVERATROL AND LIVER: A SYSTEMATIC REVIEW. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2015;20(8):797-810. Available from: https://sid.ir/paper/668069/en

    IEEE: Copy

    FOROUZAN FAGHIHZADEH, AZITA HEKMATDOOST, and PAYMAN ADIBI, “RESVERATROL AND LIVER: A SYSTEMATIC REVIEW,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 20, no. 8, pp. 797–810, 2015, [Online]. Available: https://sid.ir/paper/668069/en

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