مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

283
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

268
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CROCIN REDUCED ACRYLAMIDE‐INDUCED NEUROTOXICITY IN WISTAR RAT THROUGH INHIBITION OF OXIDATIVE STRESS

Pages

  902-908

Abstract

 Objective(s): ACRYLAMIDE (ACR) has many applications in different industries. ACR damages the central and the peripheral nervous system in human and animals. Importance of ACR‐induced NEUROTOXICITY encouraged researchers to find both different mechanisms involved in ACR NEUROTOXICITY and potent neuroprotective agents. Therefore, this study was designed to investigate the protective effect of CROCIN, an active constituent ofCrocus sativus L. (saffron) on ACR‐induced NEUROTOXICITY in Wistar rats.Materials and Methods: Animals were treated with ACR (50 mg/kg, IP) 11 days for induction NEUROTOXICITY. CROCIN (12.5, 25 and 50 mg/kg, IP) were used during treatment with ACR. At the end of treatment, GAIT SCORE EXAMINATION was performed. Then, rats were sacrificed and the severity of damage in brain tissue was determined using pathological tests. The level of malondialdehyde (MDA) and glutathione (GSH) content were evaluated in cerebral cortex and cerebellum to determine the role of oxidative stress in this model.Results: Exposure to ACR induced severe gait abnormalities and pathological changes, but administration of CROCIN markedly improved behavioral index and histopathological damages. The elevation of LIPID PEROXIDATION parallel with reduction of GSH level was observed in cerebral cortex and cerebellum following exposure to ACR. Treatment with CROCIN markedly decreased MDA level, while elevated GSH content in nervous system as compared to ACR‐treated animals.Conclusion: The administration of CROCIN markedly improved behavioral and histopathological damages in Wistar rats exposed to ACR. Reduction of oxidative stress can be considered as an important mechanism of neuroprotective effects of CROCIN against ACR‐induced toxicity.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MEHRI, SOGHRA, ABNOUS, KHALIL, KHOOEI, ALIREZA, MOUSAVI, SEYED HADI, MOTAMED SHARIATY, VAHIDEH SADAT, & HOSSEINZADEH, HOSSEIN. (2015). CROCIN REDUCED ACRYLAMIDE?INDUCED NEUROTOXICITY IN WISTAR RAT THROUGH INHIBITION OF OXIDATIVE STRESS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 902-908. SID. https://sid.ir/paper/668248/en

    Vancouver: Copy

    MEHRI SOGHRA, ABNOUS KHALIL, KHOOEI ALIREZA, MOUSAVI SEYED HADI, MOTAMED SHARIATY VAHIDEH SADAT, HOSSEINZADEH HOSSEIN. CROCIN REDUCED ACRYLAMIDE?INDUCED NEUROTOXICITY IN WISTAR RAT THROUGH INHIBITION OF OXIDATIVE STRESS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):902-908. Available from: https://sid.ir/paper/668248/en

    IEEE: Copy

    SOGHRA MEHRI, KHALIL ABNOUS, ALIREZA KHOOEI, SEYED HADI MOUSAVI, VAHIDEH SADAT MOTAMED SHARIATY, and HOSSEIN HOSSEINZADEH, “CROCIN REDUCED ACRYLAMIDE?INDUCED NEUROTOXICITY IN WISTAR RAT THROUGH INHIBITION OF OXIDATIVE STRESS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 902–908, 2015, [Online]. Available: https://sid.ir/paper/668248/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button