The Eﬀ ect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model

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Fahmi Achmad; Kuntawi Aji Yunus; Aprianto Dirga Rachmad; Wido Akbar; Asadullah Asadullah; Rouﬁ Nurkholis; Indiastuti Danti Nur; Subianto Heri; Turchan Agus

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Journal: Anesthesiology and Pain Medicine Year:2021 | Volume:11 | Issue:3 Page(s): 0-0

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Title

The Eﬀ ect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model

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Keywords

Neuropathic Pain

Intrathecal

Glucocorticoid Receptor

Dextromethorphan Hydrobromide

Abstract

Background: Peripheral Glucocorticoid Receptors (GRs) are altered by peripheral nerve injury and may modulate the development of Neuropathic Pain. Two central pathogenic mechanisms underlying Neuropathic Pain are neuroinﬂ ammation and N-methyl-Daspartate receptor (NMDAR)-dependent neural plasticity in the spinal cord. Objectives: This study examined the eﬀ ect of the non-competitive NMDAR antagonist dextromethorphan on partial sciatic nerve ligation (PSL)-induced Neuropathic Pain and the spinal expression of the Glucocorticoid Receptor (GR). Methods: Male mice were randomly assigned into a sham group and two groups receiving PSL followed by Intrathecal saline vehicle or dextromethorphan (iDMP). Vehicle or iDMP was administered 8-14 days after PSL. The hotplate paw-withdrawal latency was considered to measure thermal pain sensitivity. The spinal cord was then sectioned and immunostained for GR. Results: Thermal hyperalgesia developed similarly in the vehicle and iDMP groups prior to the injections (P = 0. 828 and 0. 643); however, it was completely mitigated during the iDMP treatment (P < 0. 001). GR expression was signiﬁ cantly higher in the vehicle group (55. 64 4. 50) than in the other groups (P < 0. 001). The iDMP group (9. 99 0. 66) showed signiﬁ cantly higher GR expression than the sham group (6. 30 1. 96) (P = 0. 043). Conclusions: The suppression of PLS-induced thermal hyperalgesia by iDMP is associated with the downregulation of GR in the spinal cord, suggesting that this analgesic eﬀ ect is mediated by inhibiting GR-regulated neuroinﬂ ammation.

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APA: Copy

Fahmi, Achmad, Kuntawi Aji, Yunus, Aprianto, Dirga Rachmad, Wido, Akbar, Asadullah, Asadullah, Rouﬁ, Nurkholis, Indiastuti, Danti Nur, Subianto, Heri, & Turchan, Agus. (2021). The Eﬀ ect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model. ANESTHESIOLOGY AND PAIN MEDICINE, 11(3), 0-0. SID. https://sid.ir/paper/668434/en

Vancouver: Copy

Fahmi Achmad, Kuntawi Aji Yunus, Aprianto Dirga Rachmad, Wido Akbar, Asadullah Asadullah, Rouﬁ Nurkholis, Indiastuti Danti Nur, Subianto Heri, Turchan Agus. The Eﬀ ect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(3):0-0. Available from: https://sid.ir/paper/668434/en

IEEE: Copy

Achmad Fahmi, Yunus Kuntawi Aji, Dirga Rachmad Aprianto, Akbar Wido, Asadullah Asadullah, Nurkholis Rouﬁ, Danti Nur Indiastuti, Heri Subianto, and Agus Turchan, “The Eﬀ ect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/668434/en

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