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Information Journal Paper

Title

ALOE VERA TOXIC EFFECTS: EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN TESTIS OF WISTAR RAT

Pages

  967-973

Abstract

 Objective(s): Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of ALOE VERA GEL (AVG) on male WISTAR RAT reproductive organ, serum NO level, and expression of iNOS gene in leydig cells.Materials and Methods: Adult male WISTAR RATs (n=36) were used for experiments in three groups. The experimental groups were orally administered with the AVG extract solution once-daily as follow: 150 mg.kg-1; group A, 300 mg.kg-1; group B, and only normal saline; group C (control group). They were mated with untreated females and the reproductive and chemical parameters were assessed for each group, including semen quality, serum testosterone, sperm fertility, gonad and body weight, serum NO concentration (by the Griess method), and iNOS gene expression (using RT-PCR).Results: The testes weight, serum testosterone, as well as sperm count and fertility of the AVG treated groups were significantly reduced when compared to the control (P<0.001). Concentration of serum NO was significantly increased (37.1±4.63 mM) in the administrated group with higher AVG concentration, compared to the control group (P<0.001; 10.19±0.87 mM); however, iNOS mRNA expression was increased in the treated animals (P<0.001).Conclusion: iNOS may play a functional role in spermatogenesis via apoptosis, reducing sperm count, but further studies are needed to illustrate the mechanisms by which AVG exerts its negative effects on spermatogenesis and sperm quality.

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    APA: Copy

    ASGHARZADEH, SAMIRA, RAFIEIAN KOPAEI, MAHMOUD, MIRZAEIAN, AMIN, REIISI, SOMAYE, & SALIMZADEH, LOGHMAN. (2015). ALOE VERA TOXIC EFFECTS: EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN TESTIS OF WISTAR RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(10), 967-973. SID. https://sid.ir/paper/668583/en

    Vancouver: Copy

    ASGHARZADEH SAMIRA, RAFIEIAN KOPAEI MAHMOUD, MIRZAEIAN AMIN, REIISI SOMAYE, SALIMZADEH LOGHMAN. ALOE VERA TOXIC EFFECTS: EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN TESTIS OF WISTAR RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(10):967-973. Available from: https://sid.ir/paper/668583/en

    IEEE: Copy

    SAMIRA ASGHARZADEH, MAHMOUD RAFIEIAN KOPAEI, AMIN MIRZAEIAN, SOMAYE REIISI, and LOGHMAN SALIMZADEH, “ALOE VERA TOXIC EFFECTS: EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) IN TESTIS OF WISTAR RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 10, pp. 967–973, 2015, [Online]. Available: https://sid.ir/paper/668583/en

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