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Information Journal Paper

Title

Comparison of the Eff ects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit

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  0-0

Abstract

 Background: Patients under mechanical ventilation in the Intensive Care Unit (ICU) have a higher risk of Delirium. To date, the ideal sedative combination for Delirium treatment in terms of cost and side eff ects has not been determined. Objectives: This study was designed to compare the eff ects of Haloperidol and Dexmedetomidine on Delirium in trauma patients under mechanical ventilation in the ICU. Methods: Sixty patients with a moderate Traumatic Brain Injury were randomly divided into two groups. Patients in the Haloperidol group received 2. 5 mg of Haloperidol intravenously every eight hours for ten minutes daily, and the Dexmedetomidine group received 0. 5  g/kg of Dexmedetomidine via intravenous infusion every other day. Delirium, agitation, length of hospitalization, duration of mechanical ventilation, and need for sedation up to seven days were measured and recorded in both groups. The Richmond Agitation-Sedation scale (RASS) and Acute Physiology and Chronic Health evaluation (APACHE II) scales were used to determine the level of agitation in patients. The Confusion Assessment method (CAM)-ICU criteria were used to determine the incidence of Delirium. Results: Based on the results of this study, age and sex of the two groups were not signifi cantly diff erent. The mean age of the patients was 36. 83 years in the Haloperidol group and 40. 1 years in the Dexmedetomidine group. After the intervention, there was no signifi cant diff erence in terms of the level of consciousness, number of days required for ventilation (P = 0. 17), and number of days in the ICU (P = 0. 49); however, there was a signifi cant diff erence between the two groups three to seven days after the intervention. Besides, there was a signifi cant diff erence between the two groups regarding the incidence of Delirium fi ve to seven days after the intervention (P < 0. 05). Conclusions: There was a signifi cant diff erence between the two groups in terms of the incidence of Delirium and the level of agitation; the patients in the Dexmedetomidine group were calmer and experienced less Delirium.

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    APA: Copy

    SOLTANI, FARHAD, Tabatabaei, Seyedkamalaldin, JANNATMAKAN, FARAHZAD, NASAJIAN, NOZAR, AMIRI, FERESHTEH, Darkhor, Roya, & Moravej, Mojtaba. (2021). Comparison of the Eff ects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit. ANESTHESIOLOGY AND PAIN MEDICINE, 11(3), 0-0. SID. https://sid.ir/paper/668807/en

    Vancouver: Copy

    SOLTANI FARHAD, Tabatabaei Seyedkamalaldin, JANNATMAKAN FARAHZAD, NASAJIAN NOZAR, AMIRI FERESHTEH, Darkhor Roya, Moravej Mojtaba. Comparison of the Eff ects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(3):0-0. Available from: https://sid.ir/paper/668807/en

    IEEE: Copy

    FARHAD SOLTANI, Seyedkamalaldin Tabatabaei, FARAHZAD JANNATMAKAN, NOZAR NASAJIAN, FERESHTEH AMIRI, Roya Darkhor, and Mojtaba Moravej, “Comparison of the Eff ects of Haloperidol and Dexmedetomidine on Delirium and Agitation in Patients with a Traumatic Brain Injury Admitted to the Intensive Care Unit,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/668807/en

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