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Information Journal Paper

Title

Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERα Positive Breast Cancer

Pages

  209-217

Abstract

 Background: The study aimed at evaluating stERoid biomarkER genes (ERα , PGR, ERβ ) and detERmining the expression level of estrogen-regulated genes (SCUB2 and BCL2) and growth factors receptors (HER2 and IGFR1) in cancER tissue samples obtained from Iranian patients with breast cancER. MoreovER, relationships with clinicopathologic aspects of tumor and response to treatment wERe studied. Methods: The current study was conducted on 246 breast tissue samples. The expression levels of these genes and their relationships with clinicopathologic aspects and treatment response wERe evaluated. Results: Based on immunohistochemistry (IHC) results, 12% of the ER negative patients expressed ERα . Comparing the effects of ERα and coexpression of BCL2 and SCUBE2 on the survival of the patients demonstrated remarkably poorER survival in ERα positive, SCUBE2, and BCL2 negative groups in comparison with othER patients, which was statistically significant in the logrank analysis (P = 0. 01). Evaluation of the effects of coexpression of HER2 and IGFR1 on patients’ survival demonstrated a worse survival rate in patients with positive expression of both receptors, which was insignificant. Conclusion: Many studies suggest that PGR alone is not enough for the functional evaluation of ERα . Evaluation of the progestERone receptor expression as well as othER genes such as ERit;color:#ff0078">ER/BLC2/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">BLC2, SCUBE2, and IGFR1, seems necessary to evaluate functionality.

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    APA: Copy

    ESMAEILI, REZVAN, MOHAMMADI, SAMANEH, Jafarbeik Iravani, Narges, Yadegari, Fatemeh, Olfatbakhsh, Asiieh, MAZAHERI, MAHTA, KAVIANI, AHMAD, REZAEI, MAHDI, & Majidzadeh A, Keivan. (2021). Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERα Positive Breast Cancer. ARCHIVES OF IRANIAN MEDICINE, 24(3), 209-217. SID. https://sid.ir/paper/669640/en

    Vancouver: Copy

    ESMAEILI REZVAN, MOHAMMADI SAMANEH, Jafarbeik Iravani Narges, Yadegari Fatemeh, Olfatbakhsh Asiieh, MAZAHERI MAHTA, KAVIANI AHMAD, REZAEI MAHDI, Majidzadeh A Keivan. Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERα Positive Breast Cancer. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2021;24(3):209-217. Available from: https://sid.ir/paper/669640/en

    IEEE: Copy

    REZVAN ESMAEILI, SAMANEH MOHAMMADI, Narges Jafarbeik Iravani, Fatemeh Yadegari, Asiieh Olfatbakhsh, MAHTA MAZAHERI, AHMAD KAVIANI, MAHDI REZAEI, and Keivan Majidzadeh A, “Expression of SCUBE2 and BCL2 Predicts Favorable Response in ERα Positive Breast Cancer,” ARCHIVES OF IRANIAN MEDICINE, vol. 24, no. 3, pp. 209–217, 2021, [Online]. Available: https://sid.ir/paper/669640/en

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