مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

LACK OF FLT3‐TKD835 GENE MUTATION IN TOXICITY OF SULFUR MUSTARD IN IRANIAN VETERANS

Pages

  862-866

Abstract

 Objective (s): SULFUR MUSTARD (SM) was used by the Iraqi army against the IRANian troops in the IRAN‐Iraq war from 1983–1988. This chemical gas affects different organs including the skin, lungs and the hematopoietic system. Any exposure to SM increases the risk of chromosomal breaking, hyperdiploidy and hypodiploidy. Studies have shown that the risk for acute myeloblastic and lymphoblastic LEUKEMIA increases in veterans exposed to SM. FLT3 mutations including ITD and TKD mutations had been observed in some cases of LEUKEMIA. Therefore, we aimed to investigate the frequency of FLT3‐ TKD835 mutations in the veterans exposed to SM agent.Materials and Methods: We studied 42 patients who were exposed to SM during the war in Khorasan Razavi province, Mashhad, IRAN in 2012. As control group, 30 healthy males were selected from firstdegree relatives of the patients. For assessment of TKD835 mutation, DNA was extracted and RFLPPCR was performed.Results: Analysis of RFLP‐PCR data showed no FLT‐3 TKD mutation in any of the patients. Conclusion: Although contact with SM can increase the risk of malignancy especially hematologic neoplasms, results of the study show that another mechanism of leukemogenesis, other than FLT3‐ TKD mutation, may be the reason for increased risk of LEUKEMIA in SM toxicity.

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    APA: Copy

    AYATOLLAHI, HOSSEIN, RAFIEE, MOHAMMAD, KERAMATI, MOHAMMAD REZA, BALALI MOOD, MAHDI, SADEGHIAN, MOHAMMAD HADI, SHEIKHI, MARYAM, AMINI, NAFISEH, ASGHARZADEH, ALI, & MORADI ZARMEHRI, AZAM. (2015). LACK OF FLT3?TKD835 GENE MUTATION IN TOXICITY OF SULFUR MUSTARD IN IRANIAN VETERANS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(9), 862-866. SID. https://sid.ir/paper/669855/en

    Vancouver: Copy

    AYATOLLAHI HOSSEIN, RAFIEE MOHAMMAD, KERAMATI MOHAMMAD REZA, BALALI MOOD MAHDI, SADEGHIAN MOHAMMAD HADI, SHEIKHI MARYAM, AMINI NAFISEH, ASGHARZADEH ALI, MORADI ZARMEHRI AZAM. LACK OF FLT3?TKD835 GENE MUTATION IN TOXICITY OF SULFUR MUSTARD IN IRANIAN VETERANS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(9):862-866. Available from: https://sid.ir/paper/669855/en

    IEEE: Copy

    HOSSEIN AYATOLLAHI, MOHAMMAD RAFIEE, MOHAMMAD REZA KERAMATI, MAHDI BALALI MOOD, MOHAMMAD HADI SADEGHIAN, MARYAM SHEIKHI, NAFISEH AMINI, ALI ASGHARZADEH, and AZAM MORADI ZARMEHRI, “LACK OF FLT3?TKD835 GENE MUTATION IN TOXICITY OF SULFUR MUSTARD IN IRANIAN VETERANS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 9, pp. 862–866, 2015, [Online]. Available: https://sid.ir/paper/669855/en

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