COMPARATIVE STUDY OF CLINICAL STAGING OF ORAL SUBMUCOUS FIBROSIS WITH QUALITATIVE ANALYSIS OF COLLAGEN FIBERS UNDER POLARIZED MICROSCOPY

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MODAK NEHA; TAMGADGE SANDHYA; TAMGADGE AVINASH; BHALERAO SUDHIR

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2015 | Volume:10 | Issue:2 Page(s): 111-119

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Title

COMPARATIVE STUDY OF CLINICAL STAGING OF ORAL SUBMUCOUS FIBROSIS WITH QUALITATIVE ANALYSIS OF COLLAGEN FIBERS UNDER POLARIZED MICROSCOPY

Author(s)

MODAK NEHA | TAMGADGE SANDHYA | TAMGADGE AVINASH | BHALERAO SUDHIR | Issue Writer Certificate

Keywords

OSMF

POLARIZATION COLORS

COLLAGEN THICKNESS

PICROSIRIUS RED STAIN

POLARIZING MICROSCOPE

Abstract

Background & Objectives: Oral submucous fibrosis (OSMF) is a condition where excessive deposition of dense collagen fibers occurred in the connective tissue of oral mucosa. An alteration of collagen necessitates an in depth understanding of collagen in oral tissues as no breakthrough studies have been reported. Therefore the aim was to correlate the clinical, functional and histopathological staging and to analyze the POLARIZATION COLORS and thickness of the collagen fibers in different stages of OSMF using PICROSIRIUS RED STAIN under polarizing microscopy so as to assess the severity of disease.Methods: The study was conducted in the department of Oral Pathology and Microbiology at Padm. Dr. D. Y Patil Dental and Hospital, Navi Mumbai, India (2012-13). A sample size was of a total 40 subjects, of which 30 patients had OSMF, and 10 were in control group. Clinical, functional and histopathological staging were done depending upon definite criteria. Collagen fibers were analyzed for polarizing colors and thickness. Further clinical, functional and histopathological stages as well as qualitative parameters of collagen fibers were compared.Results: The correlation between clinical and functional staging was not significant (P>0.05) whereas the comparison of the functional staging with histopathological staging was more reliable (P<0.01) as an indication to the severity of the disease rather than clinical staging. One-way ANOVA analysis showed highly significant correlation between functional staging and POLARIZATION COLORS and thickness of collagen fibers (P<0.001).Conclusion: The qualitative change in the collagen fibers of OSMF patients using polarized microscopy would help to assess its role in diagnostic evaluation, to determine the prognosis of the disease as well as to provide useful predictive treatment modalities to them.

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APA: Copy

MODAK, NEHA, TAMGADGE, SANDHYA, TAMGADGE, AVINASH, & BHALERAO, SUDHIR. (2015). COMPARATIVE STUDY OF CLINICAL STAGING OF ORAL SUBMUCOUS FIBROSIS WITH QUALITATIVE ANALYSIS OF COLLAGEN FIBERS UNDER POLARIZED MICROSCOPY. IRANIAN JOURNAL OF PATHOLOGY (IJP), 10(2), 111-119. SID. https://sid.ir/paper/672005/en

Vancouver: Copy

MODAK NEHA, TAMGADGE SANDHYA, TAMGADGE AVINASH, BHALERAO SUDHIR. COMPARATIVE STUDY OF CLINICAL STAGING OF ORAL SUBMUCOUS FIBROSIS WITH QUALITATIVE ANALYSIS OF COLLAGEN FIBERS UNDER POLARIZED MICROSCOPY. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2015;10(2):111-119. Available from: https://sid.ir/paper/672005/en

IEEE: Copy

NEHA MODAK, SANDHYA TAMGADGE, AVINASH TAMGADGE, and SUDHIR BHALERAO, “COMPARATIVE STUDY OF CLINICAL STAGING OF ORAL SUBMUCOUS FIBROSIS WITH QUALITATIVE ANALYSIS OF COLLAGEN FIBERS UNDER POLARIZED MICROSCOPY,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 10, no. 2, pp. 111–119, 2015, [Online]. Available: https://sid.ir/paper/672005/en

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