ANTIBACTERIAL AND TOXIC EFFECT OF HYDROGEN PEROXIDE COMBINED WITH DIFFERENT CONCENTRATIONS OF CHLORHEXIDINE IN COMPARISON WITH SODIUM HYPOCHLORITE

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MIRHADI HOSSEIN; ABBASZADEGAN ABBAS; RANJBAR MOHAMMAD ALI; AZAR MOHAMMAD REZA; GERAMIZADEH BITA; TORABI SHIMA; ALEYASIN ZEINAB SADAT; GHOLAMI AHMAD

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Journal: JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES) Year:2015 | Volume:16 | Issue:4 Page(s): 349-355

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Title

ANTIBACTERIAL AND TOXIC EFFECT OF HYDROGEN PEROXIDE COMBINED WITH DIFFERENT CONCENTRATIONS OF CHLORHEXIDINE IN COMPARISON WITH SODIUM HYPOCHLORITE

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Keywords

CHLORHEXIDINE

CYTOTOXICITY

HYDROGEN PEROXIDE

PERIODONTAL LIGAMENT CELLS

SODIUM HYPOCHLORITE

Abstract

Statement of the Problem: HYDROGEN PEROXIDE (H2O2) has been suggested to be used in sequence or in combination with CHLORHEXIDINE (CHX) to enhance the antibacterial activity against Enterococcus faecalis, but there is no research in the literature on the safety and effectiveness of this irrigation protocol.Purpose: This study aimed to assess the cytocompatibility and antibacterial activity of different concentrations of CHX combined with H2O2in comparison with the activity of 5.25 and 2.5% SODIUM HYPOCHLORITE (NaOCl).Materials and Method: Different concentrations of H2O2(10, 5, 3 and 1%) were exposed to the PDL cells. Then, the solution with minimal CYTOTOXICITY was selected (3% H2O2). The cytocompatibility and antibacterial activity of 0.1, 0.2, 1 and 2% CHX combined with 3% H2O2were evaluated and compared with 5.25 and 2.5% NaOCl. The differences in the mean viability of PDL cells were evaluated by one-way ANOVA. Kruskal-Wallis and post-hoc Dunn's tests were adopted to compare the antibacterial activity of the solutions against E. faecalis.Results: The viability of PDL cells was lower when treated with 5.25 or 2.5% NaOCl than all combinations of CHX and H2O2. There was no significant difference in the antibacterial activity of the solutions against E. faecalis, except for the 0.1% CHX + 3% H2O2combination, which had significantly lower efficacy than other groups.Conclusion: All combinations of CHX and H2O2(used in this study) except 0.1% CHX + 3% H2O2were efficient irrigants against planktonic E. faecalis and had a better cytocompatibility with PDL cells than 5.25 and 2.5% NaOCl.

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APA: Copy

MIRHADI, HOSSEIN, ABBASZADEGAN, ABBAS, RANJBAR, MOHAMMAD ALI, AZAR, MOHAMMAD REZA, GERAMIZADEH, BITA, TORABI, SHIMA, ALEYASIN, ZEINAB SADAT, & GHOLAMI, AHMAD. (2015). ANTIBACTERIAL AND TOXIC EFFECT OF HYDROGEN PEROXIDE COMBINED WITH DIFFERENT CONCENTRATIONS OF CHLORHEXIDINE IN COMPARISON WITH SODIUM HYPOCHLORITE. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), 16(4), 349-355. SID. https://sid.ir/paper/673166/en

Vancouver: Copy

MIRHADI HOSSEIN, ABBASZADEGAN ABBAS, RANJBAR MOHAMMAD ALI, AZAR MOHAMMAD REZA, GERAMIZADEH BITA, TORABI SHIMA, ALEYASIN ZEINAB SADAT, GHOLAMI AHMAD. ANTIBACTERIAL AND TOXIC EFFECT OF HYDROGEN PEROXIDE COMBINED WITH DIFFERENT CONCENTRATIONS OF CHLORHEXIDINE IN COMPARISON WITH SODIUM HYPOCHLORITE. JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2015;16(4):349-355. Available from: https://sid.ir/paper/673166/en

IEEE: Copy

HOSSEIN MIRHADI, ABBAS ABBASZADEGAN, MOHAMMAD ALI RANJBAR, MOHAMMAD REZA AZAR, BITA GERAMIZADEH, SHIMA TORABI, ZEINAB SADAT ALEYASIN, and AHMAD GHOLAMI, “ANTIBACTERIAL AND TOXIC EFFECT OF HYDROGEN PEROXIDE COMBINED WITH DIFFERENT CONCENTRATIONS OF CHLORHEXIDINE IN COMPARISON WITH SODIUM HYPOCHLORITE,” JOURNAL OF DENTISTRY (SHIRAZ UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 4, pp. 349–355, 2015, [Online]. Available: https://sid.ir/paper/673166/en

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