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Information Journal Paper

Title

Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats

Pages

  1639-1646

Abstract

 Objective(s): Regarding Lemon verbena gastroprotective effects, we investigated the protective effects of Lemon verbena extracts on reducing Gastric ulcer induced by Indomethacin. Materials and Methods: Rats received aqueous and ethanolic extracts of Lemon verbena (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of Indomethacin (100 mg/kg). Results: Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (P<0. 001). Co-administration of Indomethacin and zileuton, montelukast and ethanolic (200 mg/kg) (P<0. 001), aqueous extract (200 mg/kg) (P<0. 05) reduced ulcer compared with the Indomethacin group (P<0. 001). Ethanolic extracts (100 and 200 mg/kg) and aqueous extract (200 mg/kg) reduced the MDA level (P<0. 001). Ethanolic (50, 100, and 200 mg/kg) and aqueous extracts (200 mg/kg) significantly decreased neutrophils percentage compared with the Indomethacin group (P<0. 001). Conclusion: Aqueous and particularly ethanolic extracts of Lemon verbena have protective effects on Indomethacin-induced Gastric ulcers.

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    APA: Copy

    Mashayekhi sardoo, Habibeh, RAZAVI, BIBI MARJAN, Ekhtiari, Maryam, Kheradmand, Negar, & IMENSHAHIDI, MOHSEN. (2020). Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(12), 1639-1646. SID. https://sid.ir/paper/673681/en

    Vancouver: Copy

    Mashayekhi sardoo Habibeh, RAZAVI BIBI MARJAN, Ekhtiari Maryam, Kheradmand Negar, IMENSHAHIDI MOHSEN. Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(12):1639-1646. Available from: https://sid.ir/paper/673681/en

    IEEE: Copy

    Habibeh Mashayekhi sardoo, BIBI MARJAN RAZAVI, Maryam Ekhtiari, Negar Kheradmand, and MOHSEN IMENSHAHIDI, “Gastroprotective effects of both aqueous and ethanolic extracts of Lemon verbena leaves against indomethacin-induced gastric ulcer in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 12, pp. 1639–1646, 2020, [Online]. Available: https://sid.ir/paper/673681/en

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