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Information Journal Paper

Title

Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2

Pages

  108-115

Abstract

 Objective(s): Liqui-Mass technology has shown promising advantages in terms of commercial production and formulation manipulation. This study attempts to further explore the potential of enhanced drug release of effervescent Liqui-Pellet by optimizing certain parameters. Materials and Methods: In the current study, pellets containing co-solvent, naproxen, Coating and carrier materials were prepared via extrusion and spheronisation (Liqui-Pellet). Parameters investigated included polysorbate 80 concentration (as a co-solvent), water content and the presence or absence of neusilin US2 as part of the new binary carrier mixture approach. Results: It was found that the success of the Liqui-Pellet production was determined by the amount of polysorbate 80 and water used, where above a certain limit, agglomeration occurred, and the formulation failed. Liqui-Pellet formulation showed an excellent flow, narrow size distribution and was robust to pass friability testing. The key findings in the investigation were that the Liqui-Pellet was capable of a remarkably fast drug release, and 100% drug release achieved within 20 min at pH 1. 2, wherein naproxen has been known to be practically insoluble in such pH. Conclusion: Liqui-Pellets display the potential to enhance explosive dissolution where a combination of effervescent powders and binary carriers with the high surface area were used. Furthermore, X-ray microtomography revealed that the pellets were very uniform and homogenous.

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    APA: Copy

    Lam, Matthew, Asare Addo, Kofi, & NOKHODCHI, ALI. (2021). Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 24(1), 108-115. SID. https://sid.ir/paper/675459/en

    Vancouver: Copy

    Lam Matthew, Asare Addo Kofi, NOKHODCHI ALI. Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2021;24(1):108-115. Available from: https://sid.ir/paper/675459/en

    IEEE: Copy

    Matthew Lam, Kofi Asare Addo, and ALI NOKHODCHI, “Rapid releasing naproxen Liqui-Pellet using effervescent agent and neusilin US2,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 24, no. 1, pp. 108–115, 2021, [Online]. Available: https://sid.ir/paper/675459/en

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