FERULIC ACID PROTECTS PC12 NEURONS AGAINST HYPOXIA BY INHIBITING THE P-MAPKS AND COX-2 PATHWAYS

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LIN WEN CHIEH; PENG YU FEN; HOU CHIEN WEI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Basic Medical Sciences Year:2015 | Volume:18 | Issue:5 Page(s): 478-484

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Information Journal Paper

Title

FERULIC ACID PROTECTS PC12 NEURONS AGAINST HYPOXIA BY INHIBITING THE P-MAPKS AND COX-2 PATHWAYS

Author(s)

LIN WEN CHIEH | PENG YU FEN | HOU CHIEN WEI | Issue Writer Certificate

Keywords

CASPASE-3

FERULIC ACID

HYPOXIA

MAPKS

ROS

Abstract

Objective(s): HYPOXIA induces cellular oxidative stress that is associated with neurodegenerative diseases. Here, the protective effects of FERULIC ACID (FA) on HYPOXIA-induced neurotoxicity in PC12 cells were evaluated.Materials and Methods: We investigated the effect of FA on PC12 cells subjected to HYPOXIA stress, in vitro.Results: FA increased cell viability, prevented membrane damage (LDH release), scavenged free radicals, increased superoxide dismutase (SOD) activity, and attenuated the elevation of intracellular free Ca2+, lipid peroxidation, apoptosis (evaluated by TUNEL staining) and PGE2 production in HYPOXIA-stressed PC12 cells. MAPKS were activated during HYPOXIA. FA reduced p-p38 MAPK, CASPASE-3, and COX-2 activation which correlated well with diminished LDH release in PC12 cells under HYPOXIA. Furthermore, FA reduced lipid peroxidation in PC12 cells subjected to HYPOXIA.Conclusion: Taken together, these results indicate that FA antioxidant effects could partly be involved in inhibition of p38 MAPK pathway and apoptosis through scavenging ROS in HYPOXIA-stressed PC12 cells.

Cites

Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats

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APA: Copy

LIN, WEN CHIEH, PENG, YU FEN, & HOU, CHIEN WEI. (2015). FERULIC ACID PROTECTS PC12 NEURONS AGAINST HYPOXIA BY INHIBITING THE P-MAPKS AND COX-2 PATHWAYS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(5), 478-484. SID. https://sid.ir/paper/677865/en

Vancouver: Copy

LIN WEN CHIEH, PENG YU FEN, HOU CHIEN WEI. FERULIC ACID PROTECTS PC12 NEURONS AGAINST HYPOXIA BY INHIBITING THE P-MAPKS AND COX-2 PATHWAYS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(5):478-484. Available from: https://sid.ir/paper/677865/en

IEEE: Copy

WEN CHIEH LIN, YU FEN PENG, and CHIEN WEI HOU, “FERULIC ACID PROTECTS PC12 NEURONS AGAINST HYPOXIA BY INHIBITING THE P-MAPKS AND COX-2 PATHWAYS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 5, pp. 478–484, 2015, [Online]. Available: https://sid.ir/paper/677865/en

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