مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HAWTHORN ETHANOLIC EXTRACTS WITH TRITERPENOIDS AND FLAVONOIDS EXERT HEPATOPROTECTIVE EFFECTS AND SUPPRESS THE HYPERCHOLESTEROLEMIA‐INDUCED OXIDATIVE STRESS IN RATS

Pages

  691-699

Abstract

 Objective (s): The current study was aimed to determine the bioactive constituents and biological effects of the Crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia.Materials and Methods: Oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by HPLC. Total phenol content and radical scavenging activity of extracts were also measured. The hypocholesterolemic, ANTIOXIDANT, and HEPATOPROTECTIVE effects of the extracts were examined in hypercholesterolemic rats and compared with orlistat.Results: The highest phenol content, oleanolic acid, quercetin and lupeol levels and free radical scavenging potency were found in the bark extract, and the highest ursolic acid level was found in the berries extract. Orlistat and extracts significantly (P<0.05) lowered the hypercholesterolemiaincreased serum level of hepatic enzymes and lipid peroxidation level. Hawthorn’s extracts protected from hepatic thiol depletion and improved the lipid profile and hepatic damages.Conclusion: Data suggested that hawthorn’s extracts are able to protect from hypercholesterolemiainduced oxidative stress and hepatic injuries. Moreover, the hypocholesterolemic effect of extracts was found comparable to orlistat.

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    APA: Copy

    REZAEI GOLMISHEH, ALI, MALEKINEJAD, HASSAN, ASRI REZAEI, SIAMAK, FARSHID, AMIR ABBAS, & AKBARI, PEYMAN. (2015). HAWTHORN ETHANOLIC EXTRACTS WITH TRITERPENOIDS AND FLAVONOIDS EXERT HEPATOPROTECTIVE EFFECTS AND SUPPRESS THE HYPERCHOLESTEROLEMIA?INDUCED OXIDATIVE STRESS IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 18(7), 691-699. SID. https://sid.ir/paper/677878/en

    Vancouver: Copy

    REZAEI GOLMISHEH ALI, MALEKINEJAD HASSAN, ASRI REZAEI SIAMAK, FARSHID AMIR ABBAS, AKBARI PEYMAN. HAWTHORN ETHANOLIC EXTRACTS WITH TRITERPENOIDS AND FLAVONOIDS EXERT HEPATOPROTECTIVE EFFECTS AND SUPPRESS THE HYPERCHOLESTEROLEMIA?INDUCED OXIDATIVE STRESS IN RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2015;18(7):691-699. Available from: https://sid.ir/paper/677878/en

    IEEE: Copy

    ALI REZAEI GOLMISHEH, HASSAN MALEKINEJAD, SIAMAK ASRI REZAEI, AMIR ABBAS FARSHID, and PEYMAN AKBARI, “HAWTHORN ETHANOLIC EXTRACTS WITH TRITERPENOIDS AND FLAVONOIDS EXERT HEPATOPROTECTIVE EFFECTS AND SUPPRESS THE HYPERCHOLESTEROLEMIA?INDUCED OXIDATIVE STRESS IN RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 18, no. 7, pp. 691–699, 2015, [Online]. Available: https://sid.ir/paper/677878/en

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