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Information Journal Paper

Title

TRACHEAL OVEREXPRESSION OF IL-1β, IRAK‐1 AND TRAF‐6 MRNA IN OBESE‐ASTHMATIC MALE WISTAR RATS

Pages

  350-357

Abstract

 Objective(s): Human and animal studies have shown a close relationship between obesity and asthma severity. Here, we examined the effects of diet‐induced obesity (DIO) on the expression levels of IL‐1b, IRAK‐1 and TRAF‐6 mRNA in male Wistar rats tracheal after sensitization with ovalbumin (OVA).Materials and Methods: Twenty male Wistar rats divided to four groups, included, control group with normal diet (C+ND), OVA‐sensitized group with normal diet (S+ND), control group with high‐fat diet (C+HFD), and OVA‐sensitized group with high‐fat diet (S+HFD). All animals fed for 8 weeks with standard pelts or high‐fat diet, and then were sensitized and challenged with OVA or saline for another 4 weeks with designed regimens. At the end of study, trachea isolated and examined for expression levels of IL‐1 b, IRAK‐1 and TRAF‐6 mRNA with RT‐PCR method.Results: Diet‐induced obesity groups developed increased weight, obesity indexes and lipid profiles (P<0.05 to P<0.001). The expression levels of IL‐1 b mRNA in OVA‐sensitization groups (S+ND and S+HFD) showed a significantly increased when compared with control group. Also in S+HFD group, expression level of TRAF‐6 mRNA was higher than other groups (P<0.001). IRAK‐1 expression level was high in S+HFD compared with control group.IL‐1 b and TRAF‐6 mRNA correlated positively with obesity indexes.Conclusion: The results showed that DIO causes overexpression of IL‐1 b, IRAK‐1 and TRAF‐6 mRNA in an experimental model of asthma. Our results suggested that in obese‐asthmatic conditions locally production and activation of pro‐inflammatory agents can be increased. These findings showed that possible mechanism for obesity‐asthma relationships.

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    APA: Copy

    ASLANI, MOHAMMAD REZA, KEYHANMANESH, RANA, KHAMANEH, AMIR MAHDI, MESGARI ABBASI, MEHRAN, FALLAHI, MARYAM, & ALIPOUR, MOHAMMAD REZA. (2016). TRACHEAL OVEREXPRESSION OF IL-1β, IRAK?1 AND TRAF?6 MRNA IN OBESE?ASTHMATIC MALE WISTAR RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 19(4), 350-357. SID. https://sid.ir/paper/678471/en

    Vancouver: Copy

    ASLANI MOHAMMAD REZA, KEYHANMANESH RANA, KHAMANEH AMIR MAHDI, MESGARI ABBASI MEHRAN, FALLAHI MARYAM, ALIPOUR MOHAMMAD REZA. TRACHEAL OVEREXPRESSION OF IL-1β, IRAK?1 AND TRAF?6 MRNA IN OBESE?ASTHMATIC MALE WISTAR RATS. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2016;19(4):350-357. Available from: https://sid.ir/paper/678471/en

    IEEE: Copy

    MOHAMMAD REZA ASLANI, RANA KEYHANMANESH, AMIR MAHDI KHAMANEH, MEHRAN MESGARI ABBASI, MARYAM FALLAHI, and MOHAMMAD REZA ALIPOUR, “TRACHEAL OVEREXPRESSION OF IL-1β, IRAK?1 AND TRAF?6 MRNA IN OBESE?ASTHMATIC MALE WISTAR RATS,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 19, no. 4, pp. 350–357, 2016, [Online]. Available: https://sid.ir/paper/678471/en

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