Preparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol

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Mehrabani Yeganeh Ehsan; BAGHERI HOSSEIN; MAHJUB REZA

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Journal: Iranian Journal of Pharmaceutical Research Year:2020 | Volume:19 | Issue:3 Page(s): 45-62

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Title

Preparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol

Author(s)

Mehrabani Yeganeh Ehsan | BAGHERI HOSSEIN | MAHJUB REZA | Issue Writer Certificate

Keywords

Amphotericin B

Ion paired complexation

Distearoyl phosphatidylglycerol (DSPG)

Solid lipid nanoparticle (SLN)

Dry powder inhaler (DPI)

Lyophilization technique

Abstract

The aim of this study was to prepare dry powder inhalers (DPIs) containing Amphotericin B-loaded solid lipid nanoparticles (AMB-SLNs) as an alternative approach for prevention of pulmonary aspergillosis. For solubilizing AMB in small amounts of organic solvents ion paired complexes were firstly formed by establishing electrostatic interaction between AMB and distearoyl phosphatidylglycerol (DSPG). The SLN formulations containing AMB-DSPG complexes were prepared using glycerol monostearate (GMS) as the lipid matrix and soybean lecithin and tween 80 as the surfactants by solvent emulsification-evaporation technique. The nanoparticles were optimized through a fractional factorial design. DPIs were prepared by Lyophilization technique using lactose as the inhalational carrier and then after, the formulations were evaluated in terms of aerodynamic particle size distribution using an Andersen cascade impactor. The morphology of the particles was examined using scanning electron microscopy (SEM) and in-vitro drug release profiles were evaluated. Following the statistical results, the particle size, Poly dispersity index (PdI), zeta potential, entrapment efficiency (EE%), and drug loading (DL%) of the optimized SLNs were 187. 04 ± 11. 97 nm, 0. 188 ± 0. 028,-30. 16 ± 1. 6 mV, 89. 3 ± 3. 47 % and 2. 76 ± 0. 32 %, respectively. Formulation containing 10% w/v of lactose with the calculated fine particle fraction value as 72. 57 ± 4. 33% exhibited the appropriate aerodynamic characteristics for pulmonary drug delivery. SEM images revealed de-agglomerated particles. Invitro release studies showed sustained release of AMB from the carriers and the release kinetics were best fitted to the first order kinetic model.

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APA: Copy

Mehrabani Yeganeh, Ehsan, BAGHERI, HOSSEIN, & MAHJUB, REZA. (2020). Preparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 19(3), 45-62. SID. https://sid.ir/paper/679104/en

Vancouver: Copy

Mehrabani Yeganeh Ehsan, BAGHERI HOSSEIN, MAHJUB REZA. Preparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2020;19(3):45-62. Available from: https://sid.ir/paper/679104/en

IEEE: Copy

Ehsan Mehrabani Yeganeh, HOSSEIN BAGHERI, and REZA MAHJUB, “Preparation, Statistical Optimization and In-vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 19, no. 3, pp. 45–62, 2020, [Online]. Available: https://sid.ir/paper/679104/en

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