Celecoxib inhibits acute edema and inflammatory biomarkers through peroxisome proliferator-activated receptor-γ in rats

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HOUSHMAND GHOLAMREZA; NAGHIZADEH BAHAREH; GHORBANZADEH BEHNAM; Ghafouri Zahra; GOUDARZI MEHDI; Mansouri Mohammad Taghi

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Journal: Iranian Journal of Basic Medical Sciences Year:2020 | Volume:23 | Issue:12 Page(s): 1544-1550

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Title

Celecoxib inhibits acute edema and inflammatory biomarkers through peroxisome proliferator-activated receptor-γ in rats

Author(s)

Keywords

Carrageenan

Celecoxib

Cytokines

Oxidative stress

Pioglitazone

PPAR-γ

Rat

Abstract

Objective(s): Celecoxib (CLX), a selective cyclooxygenase-II (COX-2) inhibitor, has been used for management of several inflammatory disorders. The present study aimed to explore the role of peroxisome prolifeRator-activated receptor-gamma (PPARγ ) in CLX induced anti-inflammatory response in Rats. Materials and Methods: Carrageenan-induced paw edema was used as an acute inflammation model. Rats were treated with various intra-peritoneal (IP) doses of CLX (0. 3– 30 mg/kg) and Pioglitazone (PGL; PPARγ agonist, 1– 20 mg/kg) alone or in combination. Amounts of PPARγ , COX-2, and prostaglandin E2 (PGE2) in paw tissue, and extents of TNF-α and IL-10 in serum were measured. Moreover, levels of Oxidative stress parameters as malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx) activity in the cortex, hippocampus, and paw tissues were also determined. Results: CLX and PGL dose-dependent administRation (IP), alone or in combination reduced Carrageenan-induced paw edema. Further, both agents, alone or in combination, reduced either the amounts of COX-2, PGE2, and MDA in the inflamed paw, and the levels of TNF-α in serum which were elevated by Carrageenan. Both drugs also increased both levels of PPARγ , GSH, GPx activity in paws, and serum levels of IL-10 that were decreased by Carrageenan. Intraplantar injection of GW-9662 (IPL), a selective PPARγ antagonist, inhibited all biochemical modifications caused by both single and combined drug treatments. Conclusion: CLX produced its anti-inflammatory effects probably through PPARγ receptor activation. Besides, increased anti-inflammatory effects of CLX with PGL suggest that their combination might be applied for the clinical management of inflammation especially in patients suffering from diabetes.

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APA: Copy

HOUSHMAND, GHOLAMREZA, NAGHIZADEH, BAHAREH, GHORBANZADEH, BEHNAM, Ghafouri, Zahra, GOUDARZI, MEHDI, & Mansouri, Mohammad Taghi. (2020). Celecoxib inhibits acute edema and inflammatory biomarkers through peroxisome proliferator-activated receptor-γ in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 23(12), 1544-1550. SID. https://sid.ir/paper/679685/en

Vancouver: Copy

HOUSHMAND GHOLAMREZA, NAGHIZADEH BAHAREH, GHORBANZADEH BEHNAM, Ghafouri Zahra, GOUDARZI MEHDI, Mansouri Mohammad Taghi. Celecoxib inhibits acute edema and inflammatory biomarkers through peroxisome proliferator-activated receptor-γ in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2020;23(12):1544-1550. Available from: https://sid.ir/paper/679685/en

IEEE: Copy

GHOLAMREZA HOUSHMAND, BAHAREH NAGHIZADEH, BEHNAM GHORBANZADEH, Zahra Ghafouri, MEHDI GOUDARZI, and Mohammad Taghi Mansouri, “Celecoxib inhibits acute edema and inflammatory biomarkers through peroxisome proliferator-activated receptor-γ in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 23, no. 12, pp. 1544–1550, 2020, [Online]. Available: https://sid.ir/paper/679685/en

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