مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement

Pages

  305-314

Abstract

 Background and purpose: Gastritis is one of the most current gastrointestinal disorders worldwide. Alcohol consumption is one of the major factors, which provides gastritis. Rosmarinic acid (RA) is found in many plants and has powerful antioxidant and anti-inflammatory effects. In this study, the protective effect of RA was evaluated on the histopathological indices, antioxidant ability, and prostaglandin E2 (PGE2) secretion in male rats. Experimental approach: Forty-two animals were divided into control, ethanol-induced gastritis, and RA groups, 6 each. The protective groups included RA administration before gastritis induction at 50 mg (R-G50), 100 mg (R-G100), 150 mg (R-G150), and 200 mg (R-G200) doses. Gastritis was induced by gavage of 1 mL pure ethanol in fasted animals. After 1 h of gastritis induction, the rats were sacrificed and stomach tissue was removed. Findings/Results: Histological evaluation revealed that RA significantly attenuated gastric ulcers, leucocyte infiltration, and hyperemia. It also increased mucosal layer thickness and restored gastric glands. Furthermore, RA decreased malondialdehyde level, increased superoxide dismutase, catalase, and glutathione in the stomach tissue, and raised gastric PGE2 level. Conclusion and implications: Our study demonstrated that rosmarinic acid has a notable effect on gastritis protection that could be due to increased antioxidant defense and PGE2 secretion, eventually maintenance of mucosal barrier integrity and gastric glands.

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    APA: Copy

    HEIDARI, FATEMEH, KOMEILI MOVAHHED, TAHEREH, Hamidizad, Zeinab, & MOSLEHI, AZAM. (2021). The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 16(3), 305-314. SID. https://sid.ir/paper/680247/en

    Vancouver: Copy

    HEIDARI FATEMEH, KOMEILI MOVAHHED TAHEREH, Hamidizad Zeinab, MOSLEHI AZAM. The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2021;16(3):305-314. Available from: https://sid.ir/paper/680247/en

    IEEE: Copy

    FATEMEH HEIDARI, TAHEREH KOMEILI MOVAHHED, Zeinab Hamidizad, and AZAM MOSLEHI, “The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 16, no. 3, pp. 305–314, 2021, [Online]. Available: https://sid.ir/paper/680247/en

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