In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate

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NAZARI MOHSEN; Badmasti Farzad

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Journal Paper

Paper Information

Journal: VACCINE RESEARCH Year:2020 | Volume:7 | Issue:2 Page(s): 74-79

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Information Journal Paper

Title

In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate

Author(s)

NAZARI MOHSEN | Badmasti Farzad | Issue Writer Certificate

Keywords

Toxic Shock Syndrome Toxin-1 (TSST-1)

Vaccine target

Epitopes

Abstract

Introduction: The development of a vaccine against Staphylococcus aureus has proven to be much more difficult than expected. In this study, we considered and analyzed a mutant Toxic Shock Syndrome Toxin-1 (TSST-1) as a potential vaccine candidate. Methods: An NCBI sequence of TSST-1 was analyzed bioinformatically by online tools such as Ensemble and Pubmlst. The protein sequence of TSST-1 was similarly analysed by Expasy ProtParam, Phyre2 and Vaxign databases. The protein functional class was predicted by VICMpred database while the B-and T-cell Epitopes were predicted by IEDB and BepiPred tools. The 3D structure was predicted by LOMETS, QMEAN, ProSA-web and ElliPro. The conservation of the Epitopes was evaluated by ConSurf tool. Results: In silico analyses showed that this protein is present in high-prevalence sequence types of circulating clinical strains. It appears that TSST-1 has conserved liner and conformational B-cell Epitopes. In addition, there are four potent of T-cell Epitopes in this protein. Conclusion: This in silico data indicated that TSST-1 (and especially amino acid residues 81-221) is a promising Vaccine target against S. aureus.

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APA: Copy

NAZARI, MOHSEN, & Badmasti, Farzad. (2020). In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate. VACCINE RESEARCH, 7(2), 74-79. SID. https://sid.ir/paper/680797/en

Vancouver: Copy

NAZARI MOHSEN, Badmasti Farzad. In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate. VACCINE RESEARCH[Internet]. 2020;7(2):74-79. Available from: https://sid.ir/paper/680797/en

IEEE: Copy

MOHSEN NAZARI, and Farzad Badmasti, “In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate,” VACCINE RESEARCH, vol. 7, no. 2, pp. 74–79, 2020, [Online]. Available: https://sid.ir/paper/680797/en

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