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Information Journal Paper

Title

Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats

Author(s)

 Ghasemzadeh Rahbardar Mahboobeh | Cheraghi Farmad Hadi | HOSSEINZADEH HOSSEIN | MEHRI SOGHRA | Issue Writer Certificate 

Pages

  1041-1049

Abstract

 Objective(s): Acrylamide (ACR), has wide uses in different industries. ACR induced several toxicities including Neurotoxicity and Hepatotoxicity. The probable protective effects of Selenium on ACR-induced Neurotoxicity and Hepatotoxicity in rats were evaluated. Materials and Methods: Male Wistar rats were studied for 11 days in 8 groups: 1. Control, 2. ACR (50 mg/kg, IP), 3-5. ACR+ Selenium (0. 2, 0. 4, 0. 6 mg/kg, IP), 6. ACR+ the most effective dose of Selenium (0. 6 mg/kg, IP) three days after ACR administration, 7. ACR+ vitamin E (200 mg/kg IP, every other day) 8. Selenium (0. 6 mg/kg IP). Finally, behavioral tests were done. The levels of malondialdehyde (MDA), glutathione (GSH), Bcl-2, Bax and caspase 3 proteins in liver and cerebral cortex tissues were measured. Also, the amount of albumin, total protein, alanine transaminase (ALT) and aspartate transaminase (AST) enzymes were determined in serum. Results: ACR caused the severe motor impairment, increased MDA level and decreased GSH content, enhanced Bax/Bcl-2 ratio and caspase 3 proteins in brain and liver tissues. Besides, the level of AST was elevated while the total serum protein and albumin levels were decreased. Administration of Selenium (0. 6 mg/kg) (from the first day of the experiment and the third day) significantly recovered locomotor disorders, increased GSH content, and reduced MDA level. Also, Selenium decreased Bax/Bcl-2 ratio and caspase 3 levels in brain and liver tissues. Conclusion: The Oxidative stress and Apoptosis pathways have important roles in Neurotoxicity and Hepatotoxicity of ACR. Selenium significantly reduced ACR-induced toxicity through inhibition of Oxidative stress and Apoptosis.

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    APA: Copy

    Ghasemzadeh Rahbardar, Mahboobeh, Cheraghi Farmad, Hadi, HOSSEINZADEH, HOSSEIN, & MEHRI, SOGHRA. (2021). Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 24(8), 1041-1049. SID. https://sid.ir/paper/680837/en

    Vancouver: Copy

    Ghasemzadeh Rahbardar Mahboobeh, Cheraghi Farmad Hadi, HOSSEINZADEH HOSSEIN, MEHRI SOGHRA. Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2021;24(8):1041-1049. Available from: https://sid.ir/paper/680837/en

    IEEE: Copy

    Mahboobeh Ghasemzadeh Rahbardar, Hadi Cheraghi Farmad, HOSSEIN HOSSEINZADEH, and SOGHRA MEHRI, “Protective effects of selenium on acrylamide-induced neurotoxicity and hepatotoxicity in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 24, no. 8, pp. 1041–1049, 2021, [Online]. Available: https://sid.ir/paper/680837/en

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