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Information Journal Paper

Title

Association of CCL5 rs2107538, and CCL2 rs3760396 Gene Polymorphisms with the Risk of Cardiovascular Disease

Pages

  1436-1444

Abstract

 Background: Chemokines are proinflammatory cytokines that play key roles in development of Cardiovascular diseases (CVD). Chemokine-induced recruitment of peripheral leucocytes to tissues is a crucial step in the CVD progression. CC chemokines ligand 5, 2 (CCL5 and CCL2), have been characterized as emerging in-flammatory biomarkers of atherosclerotic CVD. The aim of this study was to find out whether genetic poly-morphisms of CCL5-403 G>A (rs2107538) and CCL2 – 927 G>C, (rs3760396) were associated with the risk of CVD. Methods: In this case-control study, 500 Iranian individuals including 250 CVD patients and 250 healthy sub-jects as the control group participated in 2017. Genotyping of CCL5-403 G>A and CCL2 – 927 G>C poly-morphisms were executed using Tetra-ARMS PCR method. Results: At genotypic level both CCL5-403 G>A and CCL2 – 927 G>C polymorphisms were not associated with the risk of CVD (P>0. 05), even after adjustment by age, sex, race, and history of hypertension, DM and smoking. However, the CCL2 – 927 C allele was associated with an increased risk of CVD (OR=1. 42, P=0. 050) with a higher prevalence in CVD patient than in controls (17% vs. 12%). Moreover, the haplotype analysis revealed that CCL5/CCL2 haplotype (G/C) was a risk factor for CVD (OR=2. 13, P=0. 001), and that carriers of this haplotype were at 2. 13-fold higher risk of CVD than subjects with G/G haplotype. Conclusion: CCL2 – 927 C variant and CCL5/CCL2 haplotype (G/C) were associated with susceptibility to CVD, and were risk factors for CVD in our population but more studies with large sample size are recom-mended.

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    APA: Copy

    Mohtavinejad, Naser, NAKHAEE, ALIREZA, Harati, Honey, Gholipour, Nazila, & Mahmoodzade, Yavar. (2021). Association of CCL5 rs2107538, and CCL2 rs3760396 Gene Polymorphisms with the Risk of Cardiovascular Disease. IRANIAN JOURNAL OF PUBLIC HEALTH, 50(7), 1436-1444. SID. https://sid.ir/paper/681017/en

    Vancouver: Copy

    Mohtavinejad Naser, NAKHAEE ALIREZA, Harati Honey, Gholipour Nazila, Mahmoodzade Yavar. Association of CCL5 rs2107538, and CCL2 rs3760396 Gene Polymorphisms with the Risk of Cardiovascular Disease. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2021;50(7):1436-1444. Available from: https://sid.ir/paper/681017/en

    IEEE: Copy

    Naser Mohtavinejad, ALIREZA NAKHAEE, Honey Harati, Nazila Gholipour, and Yavar Mahmoodzade, “Association of CCL5 rs2107538, and CCL2 rs3760396 Gene Polymorphisms with the Risk of Cardiovascular Disease,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 50, no. 7, pp. 1436–1444, 2021, [Online]. Available: https://sid.ir/paper/681017/en

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