Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A RiskBased Approach to Targeted Screening

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POUSTCHI HOSSEIN; Alaei Shahmiri Fariba; AGHILI ROKHSAREH; Nobarani Sohrab; MALEK MOJTABA; KHAMSEH MOHAMMAD E.

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Journal: ARCHIVES OF IRANIAN MEDICINE Year:2021 | Volume:24 | Issue:3 Page(s): 177-186

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Title

Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A RiskBased Approach to Targeted Screening

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Keywords

Diabetes mellitus

Hepatic steatosis

Liver fibrosis

NAFLD

Non-alcoholic fatty liver disease

Type 2

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is common in people with Type 2 Diabetes mellitus (T2DM). We aimed to explore predictive factors of NAFLD in T2DM and identify high risk subgroups. Methods: This was a cross-sectional study including 100 individuals with T2DM and 100 without diabetes matched for age, sex, and body mass index (BMI). Hepatic steatosis grades (calculated by controlled attenuation parameters-CAP score-3), and Liver fibrosis stages (F0-F4) were determined using transient elastography. Results: The frequency of NAFLD was comparable between the two study groups. However, CAP scores were significantly higher in individuals with diabetes (294. 90 ± 53. 12 vs. 269. 78 ± 45. 05 dB/m; P < 0. 001). Fifty percent of individuals with diabetes had severe steatosis (S3), while this figure was 31. 6% in those without diabetes (P < 0. 05). Significant fibrosis (F2-F4) was more frequent in individuals with T2DM (13% vs. 4. 1%, P = 0. 02). Individuals with T2DM and advanced fibrosis had significantly higher BMI, waist circumference (WC), waist-hip ratio (WHR), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and CAP score compared to those without fibrosis (P < 0. 05). In the regression analysis, a model including BMI, WHR, AST and female gender explained 50% of the variation in CAP score in patients with diabetes (all P < 0. 05, adjusted R 2: 0. 508). CAP scores were also the major determinant of Liver fibrosis in this group (OR: 1. 04; CI: 1. 017– 1. 063; P = 0. 001). Conclusion: Individuals with diabetes are more likely to have severe fibrosis. Obesity (especially central obesity), the female gender, elevated liver enzymes, and higher degree of insulin resistance are associated with more advanced liver disease in individuals with T2DM.

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APA: Copy

POUSTCHI, HOSSEIN, Alaei Shahmiri, Fariba, AGHILI, ROKHSAREH, Nobarani, Sohrab, MALEK, MOJTABA, & KHAMSEH, MOHAMMAD E.. (2021). Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A RiskBased Approach to Targeted Screening. ARCHIVES OF IRANIAN MEDICINE, 24(3), 177-186. SID. https://sid.ir/paper/681277/en

Vancouver: Copy

POUSTCHI HOSSEIN, Alaei Shahmiri Fariba, AGHILI ROKHSAREH, Nobarani Sohrab, MALEK MOJTABA, KHAMSEH MOHAMMAD E.. Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A RiskBased Approach to Targeted Screening. ARCHIVES OF IRANIAN MEDICINE[Internet]. 2021;24(3):177-186. Available from: https://sid.ir/paper/681277/en

IEEE: Copy

HOSSEIN POUSTCHI, Fariba Alaei Shahmiri, ROKHSAREH AGHILI, Sohrab Nobarani, MOJTABA MALEK, and MOHAMMAD E. KHAMSEH, “Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A RiskBased Approach to Targeted Screening,” ARCHIVES OF IRANIAN MEDICINE, vol. 24, no. 3, pp. 177–186, 2021, [Online]. Available: https://sid.ir/paper/681277/en

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