Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimotos Thyroiditis

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ESFAHANIAN FATEMEH; Mirabdolhagh Hazaveh Mojgan; Hooshmand Garehbagh Laya; Falahati Kowsar; ATAEI MITRA; SANATI MOHAMMAD HOSSEIN; JADALI ZOHREH

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Journal Paper

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Journal: Iranian Journal of Public Health Year:2021 | Volume:50 | Issue:8 Page(s): 1697-1704

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Title

Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimotos Thyroiditis

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Keywords

Mitochondrial DNA

Hashimoto's thyroiditis

Oxidative stress

Autoimmunity

Abstract

Background: The purpose of present study was to investigate Mitochondrial DNA copy number (mtDNAcn) and mtDNA damage in peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy controls (HC). Methods: The relative mtDNAcn and oxidative DNA damage in this case-control study were measured in peripheral blood of 50 patients with Hashimoto’ s thyroiditis and 50 healthy controls using quantitative real-time PCR. The study was conducted in Tehran University of Medical Sciences hospital, Tehran, Iran in 2018. Results: HT patients had significantly higher Mitochondrial DNA copy number and mitochondrial oxidative damage than the comparison group. Conclusion: These data suggest the possible involvement of mitochondria and Oxidative stress in the pathophysiology of HT.

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APA: Copy

ESFAHANIAN, FATEMEH, Mirabdolhagh Hazaveh, Mojgan, Hooshmand Garehbagh, Laya, Falahati, Kowsar, ATAEI, MITRA, SANATI, MOHAMMAD HOSSEIN, & JADALI, ZOHREH. (2021). Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimotos Thyroiditis. IRANIAN JOURNAL OF PUBLIC HEALTH, 50(8), 1697-1704. SID. https://sid.ir/paper/681432/en

Vancouver: Copy

ESFAHANIAN FATEMEH, Mirabdolhagh Hazaveh Mojgan, Hooshmand Garehbagh Laya, Falahati Kowsar, ATAEI MITRA, SANATI MOHAMMAD HOSSEIN, JADALI ZOHREH. Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimotos Thyroiditis. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2021;50(8):1697-1704. Available from: https://sid.ir/paper/681432/en

IEEE: Copy

FATEMEH ESFAHANIAN, Mojgan Mirabdolhagh Hazaveh, Laya Hooshmand Garehbagh, Kowsar Falahati, MITRA ATAEI, MOHAMMAD HOSSEIN SANATI, and ZOHREH JADALI, “Increased Mitochondrial DNA Copy Number and Oxidative Damage in Patients with Hashimotos Thyroiditis,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 50, no. 8, pp. 1697–1704, 2021, [Online]. Available: https://sid.ir/paper/681432/en

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