Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study

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Thi Ngoc Nguyen; Minh Dien Tran; Nguyen Thu Huong; Thi Phuong Luong; Thien Nam Thai; Hong Diep Pho; Trung Kien Nguyen; Viet Tien Tran; Do Quyet; Viet Thang Le

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Journal: Nephro-Urology Monthly Year:2021 | Volume:13 | Issue:3 Page(s): 0-0

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Title

Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study

Author(s)

Keywords

SLE

Pediatric Lupus Nephritis

Serum Albumin

Urine Protein/Creatinine Rate

Pathological Morphology

Abstract

Background: The current study intended to determine whether Serum Albumin level and Urine Protein/Creatinine Rate (uPCR) are appropriate predictors of severe lupus nephritis in childhood-onset SLE. Objectives: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Methods: Following a cross-sectional single-center design, 85 LN children referred to the National Children Hospital, Ha Noi, Viet Nam, from 6/2019 to 6/2020 were recruited. Renal biopsy was performed for all participants. Results: The mean SLEDAI score of all patients was 14. 69. The proportion of patients with high and very high SLEDAI was 61. 2 and 17. 6%, respectively. Themeanconcentration of serumalbuminwas 28. 55 g/L, andthe proportion of decreased albumin concentration was 55. 3%. The median uPCR was 446. 6 mg/mmol in which 76. 5% of values were 200 mg/mmol. Pathological Morphology of LN class from I to VI was observed in 0%, 17. 6%, 37. 6 %, 37. 6%, 7. 1%, and 0%, respectively. Serum Albumin level and uPCR presented the predictive value for severe and active LN (class IV and V); (AUC: 0. 725 P < 0. 001 for both). Conclusions: Serum Albumin and uPCR were appropriate predictors for severe and active LN in Vietnamese children.

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APA: Copy

Thi, Ngoc Nguyen, Minh, Dien Tran, Nguyen Thu, Huong, Thi, Phuong Luong, Thien, Nam Thai, Hong, Diep Pho, Trung, Kien Nguyen, Viet, Tien Tran, Do, Quyet, & Viet, Thang Le. (2021). Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 13(3), 0-0. SID. https://sid.ir/paper/681445/en

Vancouver: Copy

Thi Ngoc Nguyen, Minh Dien Tran, Nguyen Thu Huong, Thi Phuong Luong, Thien Nam Thai, Hong Diep Pho, Trung Kien Nguyen, Viet Tien Tran, Do Quyet, Viet Thang Le. Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2021;13(3):0-0. Available from: https://sid.ir/paper/681445/en

IEEE: Copy

Ngoc Nguyen Thi, Dien Tran Minh, Huong Nguyen Thu, Phuong Luong Thi, Nam Thai Thien, Diep Pho Hong, Kien Nguyen Trung, Tien Tran Viet, Quyet Do, and Thang Le Viet, “Association Between Hypoalbuminemia, Degree of Proteinuria, and Lupus Nephritis Class: A Single-Center Cross-Sectional Biopsy Study,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 13, no. 3, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/681445/en

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