مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells

Pages

  98-105

Abstract

 Leukemia inhibitory factor (LIF) is a multi-functional cytokine secreted from cells such as lymphocytes and hepatocytes. This study aimed to evaluate the effect of LIF on natural killer group 2 member D (NKG2D) receptors' expression and presentation on natural killer (NK) cells. For this purpose, peripheral blood mononuclear cells taken from 4 young male healthy blood donors were isolated and the effect of LIF (25 ng/mL) after 12, 24, and 48 hours of incubation, on NKG2D receptors expression and presentation was investigated using Flow Cytometry and real-timepolymerase chain reaction (PCR). All of the steps of the experiment were performed in duplicate. After periods of 12, 24, and 48 hours, LIF reduced both the expression and presentation of the NKG2D receptor on NK cells. The results suggest that this cytokine has a direct modulating activity on the body’ s immune response through suppression of NKG2D receptor expression and presentation on NK cells.

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    • Cite

    APA: Copy

    abdoli, zahra, ASSAREHZADEGAN, MOHAMMAD ALI, PIPELZADEH, MOHAMMAD HASSAN, Iranparast, Sara, Dashti Gerdabi, Nader, PARSANAHAD, MEHDI, & KHODADADI, ALI. (2021). Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 20(1), 98-105. SID. https://sid.ir/paper/682960/en

    Vancouver: Copy

    abdoli zahra, ASSAREHZADEGAN MOHAMMAD ALI, PIPELZADEH MOHAMMAD HASSAN, Iranparast Sara, Dashti Gerdabi Nader, PARSANAHAD MEHDI, KHODADADI ALI. Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2021;20(1):98-105. Available from: https://sid.ir/paper/682960/en

    IEEE: Copy

    zahra abdoli, MOHAMMAD ALI ASSAREHZADEGAN, MOHAMMAD HASSAN PIPELZADEH, Sara Iranparast, Nader Dashti Gerdabi, MEHDI PARSANAHAD, and ALI KHODADADI, “Leukemia Inhibitory Factor Suppresses NKG2D mRNA Expression and Presentation on Human Natural Killer Cells,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 20, no. 1, pp. 98–105, 2021, [Online]. Available: https://sid.ir/paper/682960/en

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