COMPARISON OF THE EFFECT OF EDIBLE CITRULLUS COLOCYNTHIS FRUIT POWDER WITH METFORMIN ON THE LEVEL OF BLOOD GLUCOSE IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

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MOJAZ DALFARDI N.; GHODRATI AZADI H.; FATHI HAFSHJANI B.

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Journal: Internal Medicine Today Year:2015 | Volume:21 | Issue:1 Page(s): 7-12

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Information Journal Paper

Title

COMPARISON OF THE EFFECT OF EDIBLE CITRULLUS COLOCYNTHIS FRUIT POWDER WITH METFORMIN ON THE LEVEL OF BLOOD GLUCOSE IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

Author(s)

MOJAZ DALFARDI N. | GHODRATI AZADI H. | FATHI HAFSHJANI B. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

CITRULLUS COLOCYNTHISQ2

METFORMINQ2

STREPTOZOCINQ2

BLOOD GLUCOSEQ3

Abstract

Aims: Diabetes is one of the metabolic diseases. According to side effects of medication and high costs of treatments, medical plants are of attention. This study was done to compare the anti-diabetic effect of CITRULLUS COLOCYNTHIS fruit powder with METFORMIN on BLOOD GLUCOSE level.Materials & Methods: 32 mature male rats with an average weight of 250-300 gr were divided into four groups; a negative control (normal diet), a positive control (distilled water), a sham (14 mg/kg METFORMIN) and a treatment (50 mg/kg CITRULLUS COLOCYNTHIS). Type 2 diabetes induced by intraperitoneal injection of 60 mg/kg of Streptozotocin (two times, with 48h interval) in all except the negative control group. These solutions regularly administrated by using oral gavage for 6 weeks. After 12 hours of fasting, before the first and after the last doses, the BLOOD GLUCOSE was measured via the tail vein. Statistical analysis was performed in SPSS 18 software by one way ANOVA with repeated measurement tests.Findings: The decreasing level of glucose between METFORMIN and CITRULLUS COLOCYNTHIS groups was significant in day 28 (p<0.05), But it was not significant in day 42.Conclusion: METFORMIN can be replaced by CITRULLUS COLOCYNTHIS in reducing BLOOD GLUCOSE.

Cites

EFFECT OF ALOEVERA WITH SWIMMING TRAINING ON THE ALANINE AMINOTRANSFERASE AND ASPARTATE AMINOTRANSFERASE LEVELS OF DIABETIC RATS

References

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APA: Copy

MOJAZ DALFARDI, N., GHODRATI AZADI, H., & FATHI HAFSHJANI, B.. (2015). COMPARISON OF THE EFFECT OF EDIBLE CITRULLUS COLOCYNTHIS FRUIT POWDER WITH METFORMIN ON THE LEVEL OF BLOOD GLUCOSE IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. OFOGH-E-DANESH, 21(1), 7-12. SID. https://sid.ir/paper/68319/en

Vancouver: Copy

MOJAZ DALFARDI N., GHODRATI AZADI H., FATHI HAFSHJANI B.. COMPARISON OF THE EFFECT OF EDIBLE CITRULLUS COLOCYNTHIS FRUIT POWDER WITH METFORMIN ON THE LEVEL OF BLOOD GLUCOSE IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. OFOGH-E-DANESH[Internet]. 2015;21(1):7-12. Available from: https://sid.ir/paper/68319/en

IEEE: Copy

N. MOJAZ DALFARDI, H. GHODRATI AZADI, and B. FATHI HAFSHJANI, “COMPARISON OF THE EFFECT OF EDIBLE CITRULLUS COLOCYNTHIS FRUIT POWDER WITH METFORMIN ON THE LEVEL OF BLOOD GLUCOSE IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS,” OFOGH-E-DANESH, vol. 21, no. 1, pp. 7–12, 2015, [Online]. Available: https://sid.ir/paper/68319/en

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