CAN TRIMODAL DISTRIBUTION OF HBS LEVELS IN SICKLE CELL TRAITS BE USED TO PREDICT THE ASSOCIATED ALPHA-THALASSEMIA FOR SCREENING CASES IN CENTRAL INDIA?

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WARPE BHUSHAN M.; SHRIKHANDE A.V.; POFLEE S.V.

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Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2016 | Volume:11 | Issue:2 Page(s): 133-137

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Title

CAN TRIMODAL DISTRIBUTION OF HBS LEVELS IN SICKLE CELL TRAITS BE USED TO PREDICT THE ASSOCIATED ALPHA-THALASSEMIA FOR SCREENING CASES IN CENTRAL INDIA?

Author(s)

WARPE BHUSHAN M. | SHRIKHANDE A.V. | POFLEE S.V. | Issue Writer Certificate

Keywords

TRIMODAL DISTRIBUTION

HBS

ALPHA-THALASSAEMIA

SICKLE CELL TRAIT

MCH

MCV

MCHC

Abstract

Background: Until now, TRIMODAL DISTRIBUTION of HBS has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. The RBC indices reduce as alpha-globin genes reduce in SICKLE CELL TRAIT (SCT) patients, which decreases the extent of intravascular sickling and thus betters the clinical course of the patients. This is a pioneer study conducted on Central Indian poor population to use the already proven six studies to screen associated alpha-thalassemia in SCT patients thus, circumventing the much costlier alpha-genotyping studies. Moreover, it aimed to study the haematological parameters in such cases.Methods: The study was performed at RHDMC, IGGMC, Nagpur, India from 2003 to 2012. The sample population was suspected cases of haemolytic anaemia. CBC and RBC indices were obtained by a cell analyzer. The sickle solubility test positively screened cases were confirmed by agar-gel haemoglobin electrophoresis at pH 8.6.Finally, quantitative assessment of haemoglobin variants was performed by HPLC.Results: Out of total 5819 cases over ten years, 933 cases were sickle heterozygotes.Overall, 180/933 subjects were predicted to be homozygous alpha-thalassemia and 338/933 were heterozygous alpha-thalassemia, based on TRIMODAL DISTRIBUTION of HBS.Conclusion: Genotyping is costlier for majority of the poor non-affording patients in Indian government set-ups, so this study is suitable to screen for associated alphathalassemia in SCT patients.

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APA: Copy

WARPE, BHUSHAN M., SHRIKHANDE, A.V., & POFLEE, S.V.. (2016). CAN TRIMODAL DISTRIBUTION OF HBS LEVELS IN SICKLE CELL TRAITS BE USED TO PREDICT THE ASSOCIATED ALPHA-THALASSEMIA FOR SCREENING CASES IN CENTRAL INDIA?. IRANIAN JOURNAL OF PATHOLOGY (IJP), 11(2), 133-137. SID. https://sid.ir/paper/683931/en

Vancouver: Copy

WARPE BHUSHAN M., SHRIKHANDE A.V., POFLEE S.V.. CAN TRIMODAL DISTRIBUTION OF HBS LEVELS IN SICKLE CELL TRAITS BE USED TO PREDICT THE ASSOCIATED ALPHA-THALASSEMIA FOR SCREENING CASES IN CENTRAL INDIA?. IRANIAN JOURNAL OF PATHOLOGY (IJP)[Internet]. 2016;11(2):133-137. Available from: https://sid.ir/paper/683931/en

IEEE: Copy

BHUSHAN M. WARPE, A.V. SHRIKHANDE, and S.V. POFLEE, “CAN TRIMODAL DISTRIBUTION OF HBS LEVELS IN SICKLE CELL TRAITS BE USED TO PREDICT THE ASSOCIATED ALPHA-THALASSEMIA FOR SCREENING CASES IN CENTRAL INDIA?,” IRANIAN JOURNAL OF PATHOLOGY (IJP), vol. 11, no. 2, pp. 133–137, 2016, [Online]. Available: https://sid.ir/paper/683931/en

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