EFFECT OF HYDROALCHOLIC EXTRACT OF CARUM COPTICUM SEED ON THE TREATMENT OF PEPTIC ULCER INDUCED BY IBUPROFEN IN RATS

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KOMEILI GHOLAM REZA; SARGAZI MEISAM; SOLUKI SIAVASH; MAALEKI SHAHABODIN; SAEIDY NEEK FATEMEH

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Journal: Internal Medicine Today Year:2012 | Volume:18 | Issue:1 (55) Page(s): 12-16

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Title

EFFECT OF HYDROALCHOLIC EXTRACT OF CARUM COPTICUM SEED ON THE TREATMENT OF PEPTIC ULCER INDUCED BY IBUPROFEN IN RATS

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Keywords

CARUM COPTICUM SEED EXTRACTQ2

IBUPROFENQ3

PEPTIC ULCERQ2

RATQ2

Abstract

Background and Aim: Non-steroidal anti-inflammatory drugs have been used widely in recent times and generation of PEPTIC ULCER is a side-effect of these drugs. In this study, we evaluated the effect of extract of Carum Copticum seed on treatment of PEPTIC ULCER induced by IBUPROFEN in RATs.Materials and Methods: This study was performed on 30 adult female RATs. At first, the animals were randomly divided into five groups. Then, in order to induce gastric ulcer, IBUPROFEN was used orally. After suffering, the animals were treated with Omeprazole or plant seed aqueous extract doses of 125, 250 and 500 mg per kg, twice a day for two weeks. Finally, the animals were studied in terms of the number and the extent of gastric ulcer. The amount of liver enzymes, Aspartate Transferase (AST) and Alkaline Transferase (ALT), in the serum of animals were also measured.Results: The plant seed extract caused a dose-dependent ulcer healing effect in RATs, that is, the therapeutic effect in doses of 125 and 250 mg/kg compared with Omeprazole was significantly meaningful (p<0.05). The mean number and area of gastric ulcers in the groups receiving the extract were significantly lower than those of the group receiving Omeprazole. The amount of liver enzymes in the extract group that received a dose of 500 mg/kg significantly increased (p<0.01).Conclusion: The extract of Carum Copticum seed was very effective in the treatment of PEPTIC ULCER and therapeutic effect of this extract is comparable with that of Omeprazole. Moreover, further work is needed to nelucidate the extent and mechanism of these changes.

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APA: Copy

KOMEILI, GHOLAM REZA, SARGAZI, MEISAM, SOLUKI, SIAVASH, MAALEKI, SHAHABODIN, & SAEIDY NEEK, FATEMEH. (2012). EFFECT OF HYDROALCHOLIC EXTRACT OF CARUM COPTICUM SEED ON THE TREATMENT OF PEPTIC ULCER INDUCED BY IBUPROFEN IN RATS. OFOGH-E-DANESH, 18(1 (55)), 12-16. SID. https://sid.ir/paper/68441/en

Vancouver: Copy

KOMEILI GHOLAM REZA, SARGAZI MEISAM, SOLUKI SIAVASH, MAALEKI SHAHABODIN, SAEIDY NEEK FATEMEH. EFFECT OF HYDROALCHOLIC EXTRACT OF CARUM COPTICUM SEED ON THE TREATMENT OF PEPTIC ULCER INDUCED BY IBUPROFEN IN RATS. OFOGH-E-DANESH[Internet]. 2012;18(1 (55)):12-16. Available from: https://sid.ir/paper/68441/en

IEEE: Copy

GHOLAM REZA KOMEILI, MEISAM SARGAZI, SIAVASH SOLUKI, SHAHABODIN MAALEKI, and FATEMEH SAEIDY NEEK, “EFFECT OF HYDROALCHOLIC EXTRACT OF CARUM COPTICUM SEED ON THE TREATMENT OF PEPTIC ULCER INDUCED BY IBUPROFEN IN RATS,” OFOGH-E-DANESH, vol. 18, no. 1 (55), pp. 12–16, 2012, [Online]. Available: https://sid.ir/paper/68441/en

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