EFFECT OF ELLAGIC ACID ON ANIMAL BEHAVIOR IN ELEVATED PLUS MAZE AND OPEN FIELD TESTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARBOOD YAGHOOB; MANSOURI SEYED MOHAMMAD TAGHI; AHMADIAN SEYYED MOSTAFA; MARD SEYYED ALI; SARKAKI ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Jentashapir Journal of Cellular and Molecular Biology Year:2015 | Volume:6 | Issue:6 Page(s): 37-44

Download Full-Text

View:

302

Download:

120

Cites:

Information Journal Paper

Title

EFFECT OF ELLAGIC ACID ON ANIMAL BEHAVIOR IN ELEVATED PLUS MAZE AND OPEN FIELD TESTS

Author(s)

Keywords

ELLAGIC ACID

ANXIETY

DIAZEPAM

FLUMAZENIL

MOTOR ACTIVITY

ELEVATED PLUS MAZE

MINIMALLY INVASIVE SURGICAL PROCEDURES

MICE

Abstract

Background: ANXIETY is one the most common psychiatric disorders. Recently, anti-oxidants have been shown to possess anxiolytic properties.Objectives: The present study aimed to investigate anxiolytic effect of ELLAGIC ACID (EA) in MICE and its interaction with GABAA receptor.Materials and Methods: 184 male albino MICE (25-30 g) were randomly assigned into two subgroups (12 groups in each). In the first set of experiments, to evaluate acute administration of EA (single dose) on ANXIETY, experimental groups (10 groups, 8 MICE per group) were control (received vehicle), EA-treated groups (received ELLAGIC ACID, 3, 10, 30 and 100 mg/kg, i.p.), DIAZEPAM (DZP)-treated groups (received DZP, 1, 3 and 5 mg/kg, i.p.), FLUMAZENIL (FLZ) + DIAZEPAM-treated group (received FLZ, 3 mg/kg and + DPZ, 5 mg/kg, i.p.) and FLZ+EA-treated group (received FLZ, 3 mg/kg and ELLAGIC ACID, 30 mg/kg, i.p.). Moreover, in the first set of experiments, to evaluate the effect of chronic administration of EA on ANXIETY, experimental groups (2 groups, 8 MICE per group) were control (received vehicle once a day for 10 days) and EA-treated group (received ELLAGIC ACID at the dose of 30 mg/kg, i.p. once a day for 10 days). In the second set of experiments, to evaluate acute (single dose) and chronic (for 10 days) administration of EA on MOTOR ACTIVITY, animal groupings were similar to the first set of experiment. ELEVATED PLUS MAZE (EPM) and open field tests used to study anxiolytic and MOTOR ACTIVITY effect of EA, respectively. Statistical analysis was performed by one-way ANOVA and post hoc Tukey’s test. P values less than 0.05 were considered as significant.Results: Acute and chronic application of EA significantly enhanced the number of open arm entries and percentage of time spent in open arm compared with the control (P<0.05). Pretreatment with FLUMAZENIL (FLZ + EA-treated group) significantly decreased the number of open arm entries and percentage of time spent in open arm compared with EA-treated group (only received EA at the dose of 30 mg/kg). ELLAGIC ACID at the dose of 100 mg/kg significantly decreased ambulatory movement compared with the control, while EA at the dose of 30 mg/kg did not affect ambulation.Conclusions: Acute and chronic administration of ELLAGIC ACID had anxiolytic property. Also, the most effective dose of ELLAGIC ACID was 30 mg/kg. Pretreatment with FLUMAZENIL reversed the beneficial effect of ELLAGIC ACID and DIAZEPAM on ANXIETY. It is likely that the anxiolytic effect of ELLAGIC ACID is largely mediated by activation of GABAA receptor.

Cites

No record.

References

No record.

Cite

APA: Copy

FARBOOD, YAGHOOB, MANSOURI, SEYED MOHAMMAD TAGHI, AHMADIAN, SEYYED MOSTAFA, MARD, SEYYED ALI, & SARKAKI, ALIREZA. (2015). EFFECT OF ELLAGIC ACID ON ANIMAL BEHAVIOR IN ELEVATED PLUS MAZE AND OPEN FIELD TESTS. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), 6(6), 37-44. SID. https://sid.ir/paper/684475/en

Vancouver: Copy

FARBOOD YAGHOOB, MANSOURI SEYED MOHAMMAD TAGHI, AHMADIAN SEYYED MOSTAFA, MARD SEYYED ALI, SARKAKI ALIREZA. EFFECT OF ELLAGIC ACID ON ANIMAL BEHAVIOR IN ELEVATED PLUS MAZE AND OPEN FIELD TESTS. JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH)[Internet]. 2015;6(6):37-44. Available from: https://sid.ir/paper/684475/en

IEEE: Copy

YAGHOOB FARBOOD, SEYED MOHAMMAD TAGHI MANSOURI, SEYYED MOSTAFA AHMADIAN, SEYYED ALI MARD, and ALIREZA SARKAKI, “EFFECT OF ELLAGIC ACID ON ANIMAL BEHAVIOR IN ELEVATED PLUS MAZE AND OPEN FIELD TESTS,” JENTASHAPIR JOURNAL OF CELLULAR AND MOLECULAR BIOLOGY (JENTASHAPIR JOURNAL OF HEALTH RESEARCH), vol. 6, no. 6, pp. 37–44, 2015, [Online]. Available: https://sid.ir/paper/684475/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops