RAPAMYCIN PROTECTS TESTES AGAINST GERM CELL APOPTOSIS AND OXIDATIVE STRESS INDUCED BY TESTICULAR ISCHEMIA-REPERFUSION

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GHASEMNEJAD BERENJI MORTEZA; GHAZI KHANSARI MAHMOUD; Yazdani Iraj; SAEEDI SARAVI SEYED SOHEIL; NOBAKHT MALIHEH; ABDOLLAHI ALIREZA; MOHAJER ANSARI JAVAD; GHASEMNEJAD BERENJI HOJJAT; PASHAPOUR SARVIN; DEHPOUR AHMAD REZA

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Journal: Iranian Journal of Basic Medical Sciences Year:2017 | Volume:20 | Issue:8 Page(s): 905-911

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Title

RAPAMYCIN PROTECTS TESTES AGAINST GERM CELL APOPTOSIS AND OXIDATIVE STRESS INDUCED BY TESTICULAR ISCHEMIA-REPERFUSION

Author(s)

Keywords

APOPTOSIS

ISCHEMIA-REPERFUSION

RAPAMYCIN

TESTICULAR TORSION

TESTIS

Abstract

Objective(s): RAPAMYCIN is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ISCHEMIA-REPERFUSION injury in several organ systems. The purpose of the present study was to examine the effect of RAPAMYCIN on testicular ISCHEMIA-REPERFUSION injury.Materials and Methods: Seventy-two adult male Wistar rats were divided into six groups: control (group1), sham-operated (Group2), T/D+DMSO as vehicle group (group3), and groups 4–6; respectively received 0.5, 1, and 1.5 mgkg-1 of RAPAMYCIN, IP 30 min before detorsion. Ischemia was achieved by twisting the right TESTIS 720o clockwise for 1 hr. The right TESTIS of 6 animals from each group were excised 4 hr after detorsion for the measurement of lipid peroxidation, caspase-3, and antioxidant enzyme activities. Histopathological changes and germ cell APOPTOSIS were determined by measuring mean of seminiferous tubules diameters (MSTD) and TUNEL test in right TESTIS of 6 animals per group, 24 hr after detorsion.Results: Testicular T/D caused increases in the APOPTOSIS, malondialdehyde (MDA), and caspase-3 levels and decreases in the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in ipsilateral TESTIS (P<0.001). The rats treated with RAPAMYCIN had significant decreases in the MDA and caspase-3 levels and significant increases in the SOD, CAT and GPx activities in ipsilateral TESTIS compared with the T/D group (P<0.001); germ cell APOPTOSIS was decreased, and MSTD was improved.Conclusion: RAPAMYCIN administration during TESTICULAR TORSION decreased ischemia/reperfusion (I/R) cellular damage.

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Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats

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APA: Copy

GHASEMNEJAD BERENJI, MORTEZA, GHAZI KHANSARI, MAHMOUD, Yazdani, Iraj, SAEEDI SARAVI, SEYED SOHEIL, NOBAKHT, MALIHEH, ABDOLLAHI, ALIREZA, MOHAJER ANSARI, JAVAD, GHASEMNEJAD BERENJI, HOJJAT, PASHAPOUR, SARVIN, & DEHPOUR, AHMAD REZA. (2017). RAPAMYCIN PROTECTS TESTES AGAINST GERM CELL APOPTOSIS AND OXIDATIVE STRESS INDUCED BY TESTICULAR ISCHEMIA-REPERFUSION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 20(8), 905-911. SID. https://sid.ir/paper/684837/en

Vancouver: Copy

GHASEMNEJAD BERENJI MORTEZA, GHAZI KHANSARI MAHMOUD, Yazdani Iraj, SAEEDI SARAVI SEYED SOHEIL, NOBAKHT MALIHEH, ABDOLLAHI ALIREZA, MOHAJER ANSARI JAVAD, GHASEMNEJAD BERENJI HOJJAT, PASHAPOUR SARVIN, DEHPOUR AHMAD REZA. RAPAMYCIN PROTECTS TESTES AGAINST GERM CELL APOPTOSIS AND OXIDATIVE STRESS INDUCED BY TESTICULAR ISCHEMIA-REPERFUSION. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2017;20(8):905-911. Available from: https://sid.ir/paper/684837/en

IEEE: Copy

MORTEZA GHASEMNEJAD BERENJI, MAHMOUD GHAZI KHANSARI, Iraj Yazdani, SEYED SOHEIL SAEEDI SARAVI, MALIHEH NOBAKHT, ALIREZA ABDOLLAHI, JAVAD MOHAJER ANSARI, HOJJAT GHASEMNEJAD BERENJI, SARVIN PASHAPOUR, and AHMAD REZA DEHPOUR, “RAPAMYCIN PROTECTS TESTES AGAINST GERM CELL APOPTOSIS AND OXIDATIVE STRESS INDUCED BY TESTICULAR ISCHEMIA-REPERFUSION,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 20, no. 8, pp. 905–911, 2017, [Online]. Available: https://sid.ir/paper/684837/en

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