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Information Journal Paper

Title

Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats

Pages

  884-892

Abstract

 Objective(s): Testicular torsion/detorsion (T/D) is a well-known cause for infertility. Pioglitazone is an agonist of peroxisome proliferator activated receptor-gamma (PPAR-γ ). Previous studies have shown that Pioglitazone has anti-inflammatory, antioxidant and antiapoptotic properties. The present study hypothesized that Pioglitazone may be protective against the testicular T/D tissue insults, and the possible pathophysiological mechanisms involved in this effect were also investigated. Materials and Methods: Rats were randomly divided into four groups: sham group, T/D group where testicular torsion was performed for 4 hr followed by 4 hr of detorsion and two Pioglitazone-treated groups (1 mg/kg and 3 mg/kg, by single intraperitoneal injection 30 min prior to detorsion). At the end of Reperfusion period, blood, ipsilateral and contralateral testicular tissue samples were obtained for biochemical and histopathological examination. Results: Pioglitazone reduced oxidative tissue damages, inflammatory mediators, and apoptotic markers and enhanced the total antioxidant status, and AMP-activated protein kinase level. Moreover, Pioglitazone improved spermatogenesis evidenced by increased Johnsen’ s score and reversed the histopathological damages induced by testicular T/D. The effects of Pioglitazone were higher with the dose of 3 mg/kg. Conclusion: Pioglitazone exhibited a protective effect against the deleterious actions of testicular T/D. This beneficial potential of Pioglitazone may be attributed to its antioxidant, anti-inflammatory and antiapoptotic properties, which was more obvious with the dose of 3 mg/kg. Pioglitazone may be a promising therapy for testicular T/D.

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    Cite

    APA: Copy

    Mahmoud, Nevertyty Mohamed, & Kabil, Soad Lotfy. (2019). Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 22(8), 884-892. SID. https://sid.ir/paper/723607/en

    Vancouver: Copy

    Mahmoud Nevertyty Mohamed, Kabil Soad Lotfy. Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2019;22(8):884-892. Available from: https://sid.ir/paper/723607/en

    IEEE: Copy

    Nevertyty Mohamed Mahmoud, and Soad Lotfy Kabil, “Pioglitazone abrogates testicular damage induced by testicular torsion/detorsion in rats,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 22, no. 8, pp. 884–892, 2019, [Online]. Available: https://sid.ir/paper/723607/en

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