VITAMIN D3 MODIFIES THE IMPACTS OF THE SUPERNATANTS OF MESENCHYMAL STEM CELLS ON MACROPHAGES FUNCTIONS

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MANSOURI MOTLAGH BAHMAN; ABTAHI FROUSHANI SEYYED MEYSAM; AFZALE AHANGARAN NAHIDEH

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Journal Paper

Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2017 | Volume:19 | Issue:6 Page(s): 0-0

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Title

VITAMIN D3 MODIFIES THE IMPACTS OF THE SUPERNATANTS OF MESENCHYMAL STEM CELLS ON MACROPHAGES FUNCTIONS

Author(s)

MANSOURI MOTLAGH BAHMAN | ABTAHI FROUSHANI SEYYED MEYSAM | AFZALE AHANGARAN NAHIDEH | Issue Writer Certificate

Keywords

VITAMIN D5

MESENCHYMAL STEM CELL

MACROPHAGE

RESPIRATORY BURST

NEUTRAL RED

VITALITY

Abstract

Background: Recent documents indicate that MESENCHYMAL STEM CELLs (MSCs) express vitamin D3 receptorsand communicate with other immunocytes. However, there is noinformation about the role of vitamin D3 on the crosstalk between MSC sand MACROPHAGEs.Objectives: The present study was done to investigate the effects of the MSCs treated with 1-25 (OH) -vitamin D3 on the some of the MACROPHAGEs functions.Methods: In this experimental study, MESENCHYMAL STEM CELLs were isolated from bone marrow of Wistar male rats (8 - 10 weeks old) and pulsed with different concentration of vitamin D3 (0, 50, 100 and 200 nM) for 48 hours. After 24 hours, the supernatants of MSCs were collected and incubated overnight with MACROPHAGEs. Next, VITALITY, NEUTRAL RED uptake, phagocytic activity, RESPIRATORY BURST, and killing activity of MACROPHAGEs were evaluated. Data were analyzed using the one-way ANOVA through SPSS software version 20.Results: The supernatants of MSCs treated with vitamin D3 could significantly enhance the MACROPHAGE VITALITY and uptake of NEUTRAL RED as well as phagocytic activity of MACROPHAGEs. Supernatants of MSCs pulsed with vitamin D3 reduced tetradecanoylphorbol acetate induced RESPIRATORY BURST of MACROPHAGEs more profoundly than the supernatants of MSCs alone. Nevertheless, the killing activity of MACROPHAGEs triggered by opsonized yeast didn’t show any significant effect by supernatants of MSCs pulsed with vitamin D3 compared to the supernatants of MSCs alone.Conclusions: The supernatants of vitamin D3 treated MSCs potentiate the anti-inflammatory functions of MSCs- educated MACROPHAGEs without any change in micro bicidal potential of MACROPHAGEs after challenge with opsonized pathogen cannot be altered.

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The Effects of Nicotine and Caffeine Treatment on the Vitality and Regenerative Potentials of Mesenchymal Stem Cells

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APA: Copy

MANSOURI MOTLAGH, BAHMAN, ABTAHI FROUSHANI, SEYYED MEYSAM, & AFZALE AHANGARAN, NAHIDEH. (2017). VITAMIN D3 MODIFIES THE IMPACTS OF THE SUPERNATANTS OF MESENCHYMAL STEM CELLS ON MACROPHAGES FUNCTIONS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 19(6), 0-0. SID. https://sid.ir/paper/684879/en

Vancouver: Copy

MANSOURI MOTLAGH BAHMAN, ABTAHI FROUSHANI SEYYED MEYSAM, AFZALE AHANGARAN NAHIDEH. VITAMIN D3 MODIFIES THE IMPACTS OF THE SUPERNATANTS OF MESENCHYMAL STEM CELLS ON MACROPHAGES FUNCTIONS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2017;19(6):0-0. Available from: https://sid.ir/paper/684879/en

IEEE: Copy

BAHMAN MANSOURI MOTLAGH, SEYYED MEYSAM ABTAHI FROUSHANI, and NAHIDEH AFZALE AHANGARAN, “VITAMIN D3 MODIFIES THE IMPACTS OF THE SUPERNATANTS OF MESENCHYMAL STEM CELLS ON MACROPHAGES FUNCTIONS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 19, no. 6, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/684879/en

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