THE EFFECT OF IRON DEFICIENCY ANEMIA (IDA) ON THE HBA2 LEVEL AND COMPARISON OF HEMATOLOGIC VALUES BETWEEN IDA AND THALASSEMIA MINOR

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KRAMATI M.R.; TAYEBI MEYBODI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Internal Medicine Today Year:2006 | Volume:11 | Issue:4 Page(s): 24-29

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Title

THE EFFECT OF IRON DEFICIENCY ANEMIA (IDA) ON THE HBA2 LEVEL AND COMPARISON OF HEMATOLOGIC VALUES BETWEEN IDA AND THALASSEMIA MINOR

Author(s)

KRAMATI M.R. | TAYEBI MEYBODI N. | Issue Writer Certificate

Keywords

HBA2Q3

HEMOGLOBIN ELECTROPHORENISQ4

ANEMIAQ3

IRON DEFICIENCYQ3

THALASSEMIA MINORQ3

Abstract

Background & Aim: The most common Hypochromic microcytic ANEMIA is IRON DEFICIENCY (IDA) and b_thalaseemiatrait. These are common in Iran and their diagnosis and distinction are important particularly in marriage consults. The results of some studies have shown that IDA can cause misdiagnosis of heterstygote b_thalassemia due to decrease in HBA2 level. Our aim of study is evaluation of effect of IDA on HBA2 levels. Furthermore hematologic values in CBC of these two disease are compared.Materials & methods: In this prospective study, 291 patients including Normal control group, heterozygote a and b_thalassemia, IDA and coexistence of IDA and B_thalassemia were evaluated for laboratory tests, including CBC, serum ferritin, Iron, TIBC and Alkaline hemoglobin clectrophoresis. Then data of patients on the basis of diagnostic criteria was accumulated in different groups and Analyzed with use of SPSS soft ware and analytical Tests.Results: HBA2 level in normal groups and IDA were %2.9±0.4 and 2.7%±0.6 respectively. in b_thalaseemia trait HBA2 was %5.6±0.9 and in coexistence of b_thalassemia and IDA was %4.7±0.1.There was a significant difference between HBA2 level in b-thalassemia and Normal Control groups and between b_thalaseemia and coexistence of b_thalaseemia and IDA. There was significant increase in RBC counts, Hb, Hct and MCHC values in b_thalaseemiatrait in comparison to IDA, but there was not significant difference in MCV between these. RDW was elevated in two diseases but it was more significant in IDA.Conclusion: IDA can cause a decrease in HBA2 level. These Particularly in cases with coexistance of IDA and b-thalassemiatrait can cause misdiagnosis. Therefore in suspicious cases of b-thalassemiatrait in IDA background, It is better to do hemoglobin electrophoresis after treatment of IDA.

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APA: Copy

KRAMATI, M.R., & TAYEBI MEYBODI, N.. (2006). THE EFFECT OF IRON DEFICIENCY ANEMIA (IDA) ON THE HBA2 LEVEL AND COMPARISON OF HEMATOLOGIC VALUES BETWEEN IDA AND THALASSEMIA MINOR. OFOGH-E-DANESH, 11(4), 24-29. SID. https://sid.ir/paper/68491/en

Vancouver: Copy

KRAMATI M.R., TAYEBI MEYBODI N.. THE EFFECT OF IRON DEFICIENCY ANEMIA (IDA) ON THE HBA2 LEVEL AND COMPARISON OF HEMATOLOGIC VALUES BETWEEN IDA AND THALASSEMIA MINOR. OFOGH-E-DANESH[Internet]. 2006;11(4):24-29. Available from: https://sid.ir/paper/68491/en

IEEE: Copy

M.R. KRAMATI, and N. TAYEBI MEYBODI, “THE EFFECT OF IRON DEFICIENCY ANEMIA (IDA) ON THE HBA2 LEVEL AND COMPARISON OF HEMATOLOGIC VALUES BETWEEN IDA AND THALASSEMIA MINOR,” OFOGH-E-DANESH, vol. 11, no. 4, pp. 24–29, 2006, [Online]. Available: https://sid.ir/paper/68491/en

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