مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SHORT COMMUNICATION: CURRENT BIOSAFETY CONSIDERATIONS IN STEM CELL THERAPY

Pages

  281-286

Abstract

 Stem cells can be valuable model systems for drug discovery and modelling human diseases as well as to investigate cellular interactions and molecular events in the early stages of development. Controlling the differentiation of stem cells into specific germ layers provides a potential source of highly specialized cells for therapeutic applications. In recent years, finding individual properties of stem cells such as their ultimate self-renewal capacity and the generation of particular cell lines by differentiation under specific culture conditions underpins the development of regenerative therapies. These futures make stem cells a leading candidate to treat a wide range of diseases. Nevertheless, as with all novel treatments, SAFETY issues are one of the barriers that should be overcome to guarantee the quality of a patient’s life after stem cell therapy. Many studies have pointed to a large gap in our knowledge about the therapeutic applications of these cells. This gap clearly shows the importance of bioSAFETY concerns for the current status of cell-based therapies, even more than their therapeutic efficacy. Currently, scientists report that TUMORIGENICITY and IMMUNOGENICITY are the two most important associated cell-based therapy risks. In principle, intrinsic factors such as cell characteristics and extrinsic elements introduced by manufacturing of stem cells can result in tumor formation and immunological reactions after stem cell transplantation. Therapeutic research shows there are many biological questions regarding SAFETY issues of stem cell clinical applications. Stem cell therapy is a rapidly advancing field that needs to focus more on finding a comprehensive technology for assessing risk. A variety of risk factors (from intrinsic to extrinsic) should be considered for safe clinical stem cell therapies.

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    • Cite

    APA: Copy

    MOUSAVINEJAD, MASOUMEH, ANDREWS, PETER W., & KARGAR SHORAKI, ELHAM. (2016). SHORT COMMUNICATION: CURRENT BIOSAFETY CONSIDERATIONS IN STEM CELL THERAPY. CELL JOURNAL (YAKHTEH), 18(2 (70)), 281-286. SID. https://sid.ir/paper/685219/en

    Vancouver: Copy

    MOUSAVINEJAD MASOUMEH, ANDREWS PETER W., KARGAR SHORAKI ELHAM. SHORT COMMUNICATION: CURRENT BIOSAFETY CONSIDERATIONS IN STEM CELL THERAPY. CELL JOURNAL (YAKHTEH)[Internet]. 2016;18(2 (70)):281-286. Available from: https://sid.ir/paper/685219/en

    IEEE: Copy

    MASOUMEH MOUSAVINEJAD, PETER W. ANDREWS, and ELHAM KARGAR SHORAKI, “SHORT COMMUNICATION: CURRENT BIOSAFETY CONSIDERATIONS IN STEM CELL THERAPY,” CELL JOURNAL (YAKHTEH), vol. 18, no. 2 (70), pp. 281–286, 2016, [Online]. Available: https://sid.ir/paper/685219/en

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