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Information Journal Paper

Title

EFFECT OF PRETREATMENT WITH EXTRACT OF ORIGANUM VULGARE LEAVES ON EXPERIMENTAL INTESTINAL ISCHEMIA-REPERFUSION INJURY IN RATS

Pages

  0-0

Abstract

 Background: ORIGANUM VULGARE is used in traditional medicine for antimicrobial, anti-inflammatory and antioxidant activities.Objectives: The present study was designed to investigate the protective effects of O. vulgare leaves extract on experimentally induced intestinal ischemia/reperfusion (I/R) injury in RATs.Materials and Methods: In this experimental study, 24 male Wistar albino RATs randomly divided into four groups. Group I/R underwent ischemia-reperfusion of the INTESTINE (45 minutes of ischemia followed by 1 hour of reperfusion). Treatment groups I and II were given O. vulgare extract (200 and 400 ppm) via oral gavages for 1 week before inducing I/R. Group sham was given normal saline orally without inducing I/R. After the experiments, the jejunum was removed and the tissues were processed for histomorphometric examination of mucosa.Results: The treatment with O. vulgare extract significantly decreased mucosal damages in the treatment groups compared to group I/R, while severe mucosal damages were observed in the group I/R. Also, there was significant difference between treatment groups I and II (P = 0.054). Group sham observed normal intestinal mucosa.Conclusions: According to the results of current study, administration of O. vulgare extract protects the intestinal mucosa from I/R injuries.

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    APA: Copy

    AZARI, OMID, KHEIRANDISH, REZA, ROHANI, HAMIDEH, & SHOJAEEPOUR, SAEEDEH. (2016). EFFECT OF PRETREATMENT WITH EXTRACT OF ORIGANUM VULGARE LEAVES ON EXPERIMENTAL INTESTINAL ISCHEMIA-REPERFUSION INJURY IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(4), 0-0. SID. https://sid.ir/paper/685220/en

    Vancouver: Copy

    AZARI OMID, KHEIRANDISH REZA, ROHANI HAMIDEH, SHOJAEEPOUR SAEEDEH. EFFECT OF PRETREATMENT WITH EXTRACT OF ORIGANUM VULGARE LEAVES ON EXPERIMENTAL INTESTINAL ISCHEMIA-REPERFUSION INJURY IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(4):0-0. Available from: https://sid.ir/paper/685220/en

    IEEE: Copy

    OMID AZARI, REZA KHEIRANDISH, HAMIDEH ROHANI, and SAEEDEH SHOJAEEPOUR, “EFFECT OF PRETREATMENT WITH EXTRACT OF ORIGANUM VULGARE LEAVES ON EXPERIMENTAL INTESTINAL ISCHEMIA-REPERFUSION INJURY IN RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/685220/en

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