IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST

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SARGOLZAEI SOUDABEH; ROUFEGARINEJAD AREZOO; SHAMSZADEH SAYNA

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Journal Paper

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Journal: Journal of Dental School Year:2016 | Volume:34 | Issue:1 Page(s): 58-65

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Information Journal Paper

Title

IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST

Author(s)

SARGOLZAEI SOUDABEH | ROUFEGARINEJAD AREZOO | SHAMSZADEH SAYNA | Issue Writer Certificate

Keywords

IMMUNOHISTOCHEMISTRY

KI-67

PCNA

PERIAPICAL GRANULOMA

RADICULAR CYST

Abstract

Objective: PERIAPICAL GRANULOMAs (PGs) and RADICULAR CYSTs (RCs), as the most common odontogenic lesions have yet unclear pathogenesis. This study was aimed to compare PCNA and KI-67 expression in PGs and RCs and evaluate their possible relationship with two lesions.Methods: In this cross-sectional descriptive study, twenty PGs and twenty RCs were evaluated immunohistochemically using an anti-PCNA and anti-Ki-67 polyclonal antibodies. PCNA+ and KI-67+ cells were counted in connective tissue wall and epithelial lining (in RCs). Statistical analysis was performed by using Mann-Whitney U test and Spearman’s rank correlation coefficient.Results: In PGs, percentage of PCNA and KI-67 expression were found 70% and 30%, respectively; In RCs, PCNA and KI-67 expression were observed 90% and 55%, respectively. Additionally, in RCS, Immunoexpression of PCNA (85%) and KI-67 (60%) were detected at epithelial lining area. The positive immunoexpression of PCNA in RCs was greater than PGs (p<0.05).Conclusion Immunoexpression of PCNA and KI-67 were detected in both lesions which may be mentioned as valuable markers for the prediction of biologic behavior of PGs and RCs.

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APA: Copy

SARGOLZAEI, SOUDABEH, ROUFEGARINEJAD, AREZOO, & SHAMSZADEH, SAYNA. (2016). IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, 34(1), 58-65. SID. https://sid.ir/paper/685272/en

Vancouver: Copy

SARGOLZAEI SOUDABEH, ROUFEGARINEJAD AREZOO, SHAMSZADEH SAYNA. IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE[Internet]. 2016;34(1):58-65. Available from: https://sid.ir/paper/685272/en

IEEE: Copy

SOUDABEH SARGOLZAEI, AREZOO ROUFEGARINEJAD, and SAYNA SHAMSZADEH, “IMMUNOHISTOCHEMICAL EXPRESSION OF PCNA AND KI-67 IN PERIAPICAL GRANULOMA AND RADICULAR CYST,” JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, vol. 34, no. 1, pp. 58–65, 2016, [Online]. Available: https://sid.ir/paper/685272/en

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