THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KALANTARI H.; MOTAHARITABAR E.; GOUDARZI M.; RASHIDI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Internal Medicine Today Year:2014 | Volume:19 | Issue:4 Page(s): 236-241

Download Full-Text

Persian Verion

View:

825

Download:

Cites:

Information Journal Paper

Title

THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MICE

Author(s)

KALANTARI H. | MOTAHARITABAR E. | GOUDARZI M. | RASHIDI M.R. | Issue Writer Certificate

Keywords

BROMOBENZENESQ2

DRUG-INDUCED LIVER INJURYQ2

TEUCRIUM POLIUM LQ2

MICEQ3

Abstract

Aims: Teucrium polium is used in Iranian traditional medicine for different diseases. In the present study, protective effect of TEUCRIUM POLIUM L. extract was investigated on bromobenzene-induced hepatotoxicity in MICE.Methods: This experimental study was performed on 48 male albino MICE. The animals were randomly divided into six groups. Groups 1 and 2 received normal saline and extract of Teucrium polium (500 mg/kg) orally for 10 days, respectively; group 3 received bromobenzene (0.36 ml/kg, ip) only on the 10th day; groups 46- received ethanolic extract orally in doses of 125, 250 and 500 mg/kg, respectively, during 10 days and bromobenzene (0.36 ml/kg, ip) on the 10th day 1 hour after the last dose of extract. Blood and liver samples were collected 24 hours after bromobenzene injection. Then, serum activity of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and directed and total bilirubin were measured. Finally, the biochemical findings were matched with histopathological verifications, the significance of the differences between groups was compared with one-way analysis of variance (ANOVA) followed by Tukey’s posttesting with P-values <0.05.Results: The results showed a significant increase in liver enzyme activity by bromobenzene. The treated groups with Teucrium polium showed significant decrease in liver enzyme activity in doses of 125, 250 and 500 mg/kg (p<0.05). Histological observations also confirmed the results.Conclusion: The results revealed that hydroalcoholic extract of Teucrium polium has protective effect on liver toxicity induced by bromobenzene.

Cites

No record.

References

No record.

Cite

APA: Copy

KALANTARI, H., MOTAHARITABAR, E., GOUDARZI, M., & RASHIDI, M.R.. (2014). THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MICE. OFOGH-E-DANESH, 19(4), 236-241. SID. https://sid.ir/paper/68531/en

Vancouver: Copy

KALANTARI H., MOTAHARITABAR E., GOUDARZI M., RASHIDI M.R.. THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MICE. OFOGH-E-DANESH[Internet]. 2014;19(4):236-241. Available from: https://sid.ir/paper/68531/en

IEEE: Copy

H. KALANTARI, E. MOTAHARITABAR, M. GOUDARZI, and M.R. RASHIDI, “THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE-INDUCED HEPATOTOXICITY IN MICE,” OFOGH-E-DANESH, vol. 19, no. 4, pp. 236–241, 2014, [Online]. Available: https://sid.ir/paper/68531/en

Related Journal Papers