STUDY OF THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT MICROEMULSION OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE -INDUCED HEPATOTOXICITY IN MICE

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RAHMANI ALIHASAN; RASHIDI NOOSHABADI MOHAMADREZA; HOUSHMAND GHOLAMREZA; GOUDARZI MAHDI

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Journal: Yafteh Year:2014 | Volume:16 | Issue:3 (61) Page(s): 93-101

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Title

STUDY OF THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT MICROEMULSION OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE -INDUCED HEPATOTOXICITY IN MICE

Author(s)

RAHMANI ALIHASAN | RASHIDI NOOSHABADI MOHAMADREZA | HOUSHMAND GHOLAMREZA | GOUDARZI MAHDI | Issue Writer Certificate

Keywords

BROMOBENZENEQ2

MICROEMULSIONSQ1

TEUCRIUM POLIUMQ2

HEPATOTOXICITYQ2

MICEQ3

Abstract

Background: Liver is a major organ of the body, which can be exposed to various chemicals, drugs and many other xenobiotics such as BROMOBENZENE. The aim of this study was to find out the protective effect of hydroalcoholic extract microemulsion of TEUCRIUM POLIUM against HEPATOTOXICITY induced by BROMOBENZENE.Materials and Methods: Animals were divided into eight groups, with ten animals in each group. Group 1-3 received respectively normal saline; base of microemulsion and extract MICROEMULSIONS in dose of 400 mg/kg orally for 10 days. Group 4 received BROMOBENZENE (0.36 ml/kg, ip) only on the 10th day; groups 5-8 received extract MICROEMULSIONS orally in doses of 50, 100, 200and 400 mg/kg respectively, during 10 days and BROMOBENZENE (0.36 ml/kg, ip) on the 10th day 1 hour after last dose of extract. 24 hours later, the animals were bled and enzymes ALT, AST and ALP were measured. Animal liver was removed for histological studies.Results: The results showed a significant increase in liver enzyme activity by BROMOBENZENE. The treated groups with TEUCRIUM POLIUM showed a significant decrease in liver enzyme activity in doses of 100, 200 and 400 mg/kg (P<0.05). Histological observations also confirmed the results.Conclusion: The results revealed that hydroalcoholic extract microemulsion of TEUCRIUM POLIUM has protective effect on liver toxicity induced by BROMOBENZENE.

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APA: Copy

RAHMANI, ALIHASAN, RASHIDI NOOSHABADI, MOHAMADREZA, HOUSHMAND, GHOLAMREZA, & GOUDARZI, MAHDI. (2014). STUDY OF THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT MICROEMULSION OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE -INDUCED HEPATOTOXICITY IN MICE. YAFTEH, 16(3 (61)), 93-101. SID. https://sid.ir/paper/79985/en

Vancouver: Copy

RAHMANI ALIHASAN, RASHIDI NOOSHABADI MOHAMADREZA, HOUSHMAND GHOLAMREZA, GOUDARZI MAHDI. STUDY OF THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT MICROEMULSION OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE -INDUCED HEPATOTOXICITY IN MICE. YAFTEH[Internet]. 2014;16(3 (61)):93-101. Available from: https://sid.ir/paper/79985/en

IEEE: Copy

ALIHASAN RAHMANI, MOHAMADREZA RASHIDI NOOSHABADI, GHOLAMREZA HOUSHMAND, and MAHDI GOUDARZI, “STUDY OF THE PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT MICROEMULSION OF TEUCRIUM POLIUM L. AGAINST BROMOBENZENE -INDUCED HEPATOTOXICITY IN MICE,” YAFTEH, vol. 16, no. 3 (61), pp. 93–101, 2014, [Online]. Available: https://sid.ir/paper/79985/en

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