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Information Journal Paper

Title

The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication

Pages

  229-236

Abstract

 Background: Non-ionic surfactant, Tween-80 (TW80) is commonly used for drug delivery due to its effect on the cell membrane permeation. The change in permeability can also increase viral infectivity in cells. This study was undertaken to improve upon Newcastle disease virus (NDV) titer cultivated with embryonic chicken eggs. Methods: The toxicity of TW80 was investigated against chicken embryos at varying concentrations, and changes in the morphology and weights of the heart, liver, and spleen of 4-day old chicken embryos were analyzed. Also, the effect of non-toxic concentrations of TW80 was examined on the infectivity of NDV. The virus was titrated in the allantoic fluid, using a 50% embryo infectious dose (EID50 ). Results: At high concentrations of TW80, hemorrhage-induced mortality was observed in embryos at the early stages of incubation. The embryos’ viability was not affected at low TW80 concentrations, indicating that its toxicity to the chicken embryos was dose-dependent. The infectivity titer of NDV was increased in the presence of TW80 compared to those inoculated with NDV only. Conclusion: The data suggest that TW80 is toxic to chicken embryos at high concentrations, but it enhances cell membrane permeability for NDV particles at low concentrations without affecting the embryos' viability.

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    APA: Copy

    SHAHSAVANDI, SHAHLA, EBRAHIMI, MOHAMMAD MAJID, Ghadiri, Mohammad Bagher, & Samiee, Mohammad Reza. (2020). The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication. IRANIAN JOURNAL OF TOXICOLOGY, 14(4), 229-236. SID. https://sid.ir/paper/685692/en

    Vancouver: Copy

    SHAHSAVANDI SHAHLA, EBRAHIMI MOHAMMAD MAJID, Ghadiri Mohammad Bagher, Samiee Mohammad Reza. The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication. IRANIAN JOURNAL OF TOXICOLOGY[Internet]. 2020;14(4):229-236. Available from: https://sid.ir/paper/685692/en

    IEEE: Copy

    SHAHLA SHAHSAVANDI, MOHAMMAD MAJID EBRAHIMI, Mohammad Bagher Ghadiri, and Mohammad Reza Samiee, “The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication,” IRANIAN JOURNAL OF TOXICOLOGY, vol. 14, no. 4, pp. 229–236, 2020, [Online]. Available: https://sid.ir/paper/685692/en

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