Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus armeniaca L. )

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Vahedi Mazdabadi Yasaman; Karimpour Razkenari Elahe; AKBARZADEH TAHMINEH; Lotfian Hania; TOUSHIH MOHAMMAD; ROSHANRAVAN NEDA; SAEEDI MINA; OSTADRAHIMI ALIREZA

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Journal: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH Year:2020 | Volume:19 | Issue:4 Page(s): 216-224

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Title

Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus armeniaca L. )

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Keywords

Alzheimer's disease

Amygdalin

Cholinesterase inhibitors

Neuroprotectivity

P. armeniaca

Abstract

Apricot (Prunus armeniaca L. ) is a fruit cultivated in various parts of the world. Both sweet and bitter kernels of apricot have been used for the treatment of different diseases such as loss of memory in Iranian traditional medicine (ITM). In the present study, the inhibitory activity of sweet and bitter extracts of apricot kernels towards cholinesterase (ChE) enzymes, both acetyl and butyrylcholinesterase was examined through Ellman’ s method. In addition, neuroprotectivity of aqueous extracts and amygdalin were investigated against H2 O2-induced cell death in PC12 neurons. Among them, the best acetylcholinesterase (AChE) inhibitory activity (IC50 = 134. 93 ± 2. 88 µ g/mL) and neuroprotectivity (P-value < 0. 0001) were obtained by the aqueous extract of bitter type. It was found that all extracts showed no butyrylcholinesterase (BChE) inhibitory activity.

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APA: Copy

Vahedi Mazdabadi, Yasaman, Karimpour Razkenari, Elahe, AKBARZADEH, TAHMINEH, Lotfian, Hania, TOUSHIH, MOHAMMAD, ROSHANRAVAN, NEDA, SAEEDI, MINA, & OSTADRAHIMI, ALIREZA. (2020). Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus armeniaca L. ). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 19(4), 216-224. SID. https://sid.ir/paper/685726/en

Vancouver: Copy

Vahedi Mazdabadi Yasaman, Karimpour Razkenari Elahe, AKBARZADEH TAHMINEH, Lotfian Hania, TOUSHIH MOHAMMAD, ROSHANRAVAN NEDA, SAEEDI MINA, OSTADRAHIMI ALIREZA. Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus armeniaca L. ). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2020;19(4):216-224. Available from: https://sid.ir/paper/685726/en

IEEE: Copy

Yasaman Vahedi Mazdabadi, Elahe Karimpour Razkenari, TAHMINEH AKBARZADEH, Hania Lotfian, MOHAMMAD TOUSHIH, NEDA ROSHANRAVAN, MINA SAEEDI, and ALIREZA OSTADRAHIMI, “Anti-cholinesterase and Neuroprotective Activities of Sweet and Bitter Apricot Kernels (Prunus armeniaca L. ),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 19, no. 4, pp. 216–224, 2020, [Online]. Available: https://sid.ir/paper/685726/en

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