Seroprevalence of Herpes Simplex Virus Type 2 and Human Herpesvirus Type 8 among Prostate Cancer Patients Compared to Cancer-Free Men

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OHADIAN MOGHADAM SOLMAZ; MANSORI KAMYAR; NOWROOZI MOHAMMAD REZA; AFSHAR DAVOUD; NOWROOZI ALI

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Journal Paper

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Journal: International Journal of Cancer Management Year:2021 | Volume:14 | Issue:4 Page(s): 0-0

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Title

Seroprevalence of Herpes Simplex Virus Type 2 and Human Herpesvirus Type 8 among Prostate Cancer Patients Compared to Cancer-Free Men

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Keywords

Prostate Cancer

Herpes Simplex Virus Type 2

Human Herpesvirus 8

Sexually Transmitted Infections

Enzyme-Linked Immunosorbent Assay

Seroprevalence

Abstract

Background: As one of the most prevalent cancers in men, Prostate Cancer is a condition with multiple causes. Viral infections have been identified as one of the major sources of elevated incidence of Prostate Cancer. Objectives: The purpose of this research was to assess the association of the risk of Prostate Cancer and its aggressiveness with seropositivity of herpes simplex virus 2 (HSV-2) and/or Human Herpesvirus 8 (HHV-8). Methods: Totally, 103 men with Prostate Cancer as cases and 81 healthy individuals as controls were included in this case-control analysis and provided a serum sample. The specific IgG antibodies against HSV-2 and HHV-8 were screened by Enzyme-Linked Immunosorbent Assay (ELISA). To determine the association between HSV-2, HHV-8, prostate-specific antigen (PSA) level, and demographic variables with incidence of Prostate Cancer, univariate and multivariate logistic regression models were applied. Results: The results of the univariate logistic regression model showed a statistically significant association between HSV-2 and HHV-8 seropositivity, PSA level, age, and smoking with Prostate Cancer incidence (P 0. 20). The multivariate logistic regression model results after adjusting for the potential confounding variables showed a significant statistical association between the mean of PSA level [adjusted odds ratio (OR): 3. 44; 95% CI: 2. 15-5. 51; P < 0. 001) and incidence of Prostate Cancer. Moreover, the results of univariate and multivariate logistic regression model showed a significant statistical association between age [adjusted OR: 0. 88; 95% confidence interval (CI): 0. 81-0. 95; P = 0. 001] and HSV-2 and also significant statistical association was found between PSA (adjusted OR: 1. 02; 95% CI: 1. 005-1. 03; P = 0. 006) and HHV-8. Conclusions: Although the Seroprevalence of HSV-2 and HHV-8 was higher in patients with Prostate Cancer than in the control group, it cannot be concluded that there is a significant association between the seropositivity of these viruses and Prostate Cancer incidence. However, the findings showed a significant statistical association between age and seropositivity of HSV-2 and also a significant statistical association between PSA levels and seropositivity of HHV-8.

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APA: Copy

OHADIAN MOGHADAM, SOLMAZ, MANSORI, KAMYAR, NOWROOZI, MOHAMMAD REZA, AFSHAR, DAVOUD, & NOWROOZI, ALI. (2021). Seroprevalence of Herpes Simplex Virus Type 2 and Human Herpesvirus Type 8 among Prostate Cancer Patients Compared to Cancer-Free Men. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), 14(4), 0-0. SID. https://sid.ir/paper/686017/en

Vancouver: Copy

OHADIAN MOGHADAM SOLMAZ, MANSORI KAMYAR, NOWROOZI MOHAMMAD REZA, AFSHAR DAVOUD, NOWROOZI ALI. Seroprevalence of Herpes Simplex Virus Type 2 and Human Herpesvirus Type 8 among Prostate Cancer Patients Compared to Cancer-Free Men. INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION)[Internet]. 2021;14(4):0-0. Available from: https://sid.ir/paper/686017/en

IEEE: Copy

SOLMAZ OHADIAN MOGHADAM, KAMYAR MANSORI, MOHAMMAD REZA NOWROOZI, DAVOUD AFSHAR, and ALI NOWROOZI, “Seroprevalence of Herpes Simplex Virus Type 2 and Human Herpesvirus Type 8 among Prostate Cancer Patients Compared to Cancer-Free Men,” INTERNATIONAL JOURNAL OF CANCER MANAGEMENT (IRANIAN JOURNAL OF CANCER PREVENTION), vol. 14, no. 4, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/686017/en

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