AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection

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ZHANG LU; LI Ming Hui; Yi Wei; LU YAO; WuWu Shu Ling; Hao Hong xiao; Gao Yuan jiao; Lu Hui hui; Chen Qiqi; Shen Ge; Chang Ming; Hu Lei Ping; Liu Ru Yu; Sun Lei; Wan Gang; Xie Yao

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Journal: Hepatitis Monthly Year:2020 | Volume:20 | Issue:10 Page(s): 0-0

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Title

AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection

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Keywords

Alanine Aminotransferase (ALT)

Aspartate Aminotransferase (AST)

Cut Off

Chronic Hepatitis B

Hepatitis B Surface Antigen (HBsAg)

Hepatitis B E Antigen (HBeAg)

Liver Inflammation

Abstract

Objectives: The current study aimed to investigate the characteristics of HBV serum markers (HBsAg, HBeAg), biochemical indicators, HBV DNA, and the age to distinguish minimal from non-minimal liver histological inflammation group in HBeAg-positive chronic HBV-infected patients with ALT 1ULN (40U/L). Methods: The HBeAg-positive patients with treatment-naï ve hospitalized at Ditan hospital from January 2008 to January 2017 are investigated. Patients were separated into two groups of minimal and non-minimal (mild and moderate) histological inflammation group by liver biopsy specimens. Data were analyzed using the SPSS package. Results: There were both positive (age, ALT, and AST) and negative correlation factors (serum HBsAg, HBeAg, or HBV DNA quantitation) to the Liver Inflammation grades. Multivariate regression analysis indicated that HBeAg (P < 0. 001, b =-0. 554, Exp (B) = 0. 575) and AST (P = 0. 003, b = 0. 074, Exp (B) = 1. 077) were independent influential factors. The cutoff values of HBeAg and AST were separately 2. 85 Log10S/CO (AUC0. 724, Sensitivity64%, Specificity79%), 28U/L (AUC0. 726, Sensitivity68%, Specificity 78%) to distinguish Minimal from Non-minimal liver histological inflammation in chronic HBV-infected patients with ALT 1 ULN (40U/L). Conclusions: In total, 31. 34% (115/367) of patients with chronic HBV infectionwhohad non-minimal (mild and moderate) liver histological inflammation reached the required inflammation levels for antiviral treatment in HBeAg-positive patients with persistently normal ALT. HBeAg (cutoff < 2. 85 Log10S/CO) and AST (cutoff > 28 U/L) were the independent influential factors of predicting nonminimal Liver Inflammation with ALT 1 ULN (40U/L).

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APA: Copy

ZHANG, LU, LI, Ming Hui, Yi, Wei, LU, YAO, WuWu, Shu Ling, Hao, Hong xiao, Gao, Yuan jiao, Lu, Hui hui, Chen, Qiqi, Shen, Ge, Chang, Ming, Hu, Lei Ping, Liu, Ru Yu, Sun, Lei, Wan, Gang, & Xie, Yao. (2020). AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection. HEPATITIS MONTHLY, 20(10), 0-0. SID. https://sid.ir/paper/687490/en

Vancouver: Copy

ZHANG LU, LI Ming Hui, Yi Wei, LU YAO, WuWu Shu Ling, Hao Hong xiao, Gao Yuan jiao, Lu Hui hui, Chen Qiqi, Shen Ge, Chang Ming, Hu Lei Ping, Liu Ru Yu, Sun Lei, Wan Gang, Xie Yao. AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection. HEPATITIS MONTHLY[Internet]. 2020;20(10):0-0. Available from: https://sid.ir/paper/687490/en

IEEE: Copy

LU ZHANG, Ming Hui LI, Wei Yi, YAO LU, Shu Ling WuWu, Hong xiao Hao, Yuan jiao Gao, Hui hui Lu, Qiqi Chen, Ge Shen, Ming Chang, Lei Ping Hu, Ru Yu Liu, Lei Sun, Gang Wan, and Yao Xie, “AST and HBeAg Level Can Help to Distinguish Non-Minimal Liver Inflammation in Persistently Normal Alanine Aminotransferase of Chronic HBV Infection,” HEPATITIS MONTHLY, vol. 20, no. 10, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/687490/en

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